Controversial Role of Kisspeptins/KiSS-1R Signaling System in Tumor Development

Frontiers in Endocrinology
Federica FratangeloMaria Letizia Motti

Abstract

KiSS-1 was first described as a metastasis suppressor gene in malignant melanoma. KiSS-1 encodes a 145 amino-acid residue peptide that is further processed, producing the 54 amino acid metastin and shorter peptides collectively named kisspeptins (KPs). KPs bind and activate KiSS-1R (GPR54). Although the KPs system has been extensively studied for its role in endocrinology of reproductive axis in mammals, its role in cancer is still controversial. Experimental evidences show that KP system exerts an anti-metastatic effect by the regulation of cellular migration and invasion in several cancer types. However, the role of KPs/KiSS-1R is very complex. Genomic studies suggest that KiSS-1/KiSS-1R expression might be different in the various stages of tumor development. Furthermore, overexpression of KiSS-1R has been reported to elicit drug resistance in triple negative breast cancer. In this review, we focused on multiple functions exerted by the KPs/KiSS-1R system in regulating tumor progression.

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Citations

Jul 25, 2019·International Journal of Environmental Research and Public Health·Maria Letizia Motti, Rosaria Meccariello
Nov 11, 2019·Cancer Metastasis Reviews·Ilya V UlasovDanny R Welch
Dec 15, 2020·British Journal of Biomedical Science·M FarsimadanH Vaziri

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Methods Mentioned

BETA
PCR
acetylation

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