Controversies and unresolved issues in antiphospholipid syndrome pathogenesis and management

Hematology/oncology Clinics of North America
William F BakerJawed Fareed

Abstract

While much is understood concerning the clinical features of patients with antiphospholipid syndrome (APS), many issues remain. The proper designation of patients with "definite" APS and the correct categorization of patients by both laboratory and clinical features are matters of ongoing debate. Recent proposals have identified new subsets of patients who have many typical features of APS but either do not fit the criteria for a "definite" diagnosis or have initially negative laboratory tests for antiphospholipid antibodies. Meanwhile, decisions about laboratory tests are based on expert opinion, rather than the results of controlled trials. As for treatment, many guidelines are offered, but few are backed by data from strong clinical trials. This article summarizes the clinical questions remaining to be answered and debates concerning pathogenesis, diagnosis, and management.

References

Aug 15, 1992·Annals of Internal Medicine·M H Rosove, P M Brewer
Oct 25, 1991·Journal of Immunological Methods·J ArvieuxM G Colomb
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H P McNeilS A Krilis
Aug 1, 1987·The Journal of Clinical Investigation·E H RehmusO D Ratnoff
Jan 1, 1987·Clinical Immunology and Immunopathology·D W BranchJ R Scott
Oct 29, 1986·Biochimica Et Biophysica Acta·J NimpfR F Zwaal
Oct 1, 1985·Annals of the Rheumatic Diseases·J EfthimiouG R Hughes
Jan 1, 1995·Clinical Reviews in Allergy & Immunology·N AbuafA M Rouquette
Apr 13, 1995·The New England Journal of Medicine·M A KhamashtaG R Hughes
Jan 1, 1997·British Journal of Rheumatology·M TeixidóA Ordinas
Aug 1, 1997·Annals of Internal Medicine·S Moll, T L Ortel
May 12, 1998·The American Journal of Medicine·C S Kitchens
Aug 13, 1998·Seminars in Thrombosis and Hemostasis·M IekoT Koike
Jan 16, 1999·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·M JankowskiJ Musial
Aug 12, 1999·Seminars in Thrombosis and Hemostasis·R L Bick, W F Baker
Mar 22, 2000·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·J M WalengaR L Bick
Mar 22, 2000·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·N RegéczyG Szegedi
Jun 9, 2000·Clinical and Experimental Immunology·J G Hanly, S A Smith
Jul 18, 2000·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·R L Bick
Sep 2, 2000·Journal of Autoimmunity·L O CarrerasM E Martinuzzo
Sep 2, 2000·Journal of Autoimmunity·J RauchJ S Levine
Sep 2, 2000·Journal of Autoimmunity·S S PierangeliE N Harris
Sep 6, 2001·Rheumatic Diseases Clinics of North America·A E GharaviE N Harris
Jan 17, 2002·The New England Journal of Medicine·J P MohrUNKNOWN Warfarin-Aspirin Recurrent Stroke Study Group
Apr 9, 2002·Fertility and Sterility·Nicoletta Di SimoneAlessandro Caruso
May 7, 2002·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Rolandas GerbutaviciusRasa Griniute
Jul 12, 2002·The New England Journal of Medicine·Phillip Periman
Mar 12, 2003·Hematology/oncology Clinics of North America·Rodger L Bick
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·J Arnout, J Vermylen
Aug 2, 2003·Lupus·R A AshersonUNKNOWN Catastrophic Antiphospholipid Syndrome Registry Project Group

❮ Previous
Next ❯

Citations

Dec 9, 2009·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Alejandro Gru, Louis P Dehner
Sep 8, 2009·Progress in Cardiovascular Diseases·Diane George, Doruk Erkan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Autoimmune Polyendocrinopathies

Autoimmune polyendocrinopathies, also called polyglandular autoimmune syndromes (PGASs), or polyendocrine autoimmune syndromes(PASs), are a heterogeneous group of rare diseases characterized by autoimmune activity against more than one endocrine organ, although non-endocrine organs can be affected. Discover the latest research on autoimmune polyendocrinopathies here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Blood Coagulation Signaling Pathways

Coagulation is the process by which a blood clot is formed. This process includes both the formation of a platelet plug as well as a cascade of clotting factors resulting in the formation of fibrin strands. Find the latest research on coagulation signaling pathways here.

Autoimmune Polyendocrine Syndromes

This feed focuses on a rare genetic condition called Autoimmune Polyendocrine Syndromes, which are characterized by autoantibodies against multiple endocrine organs. This can lead to Type I Diabetes.

Antiphospholipid Syndrome

Antiphospholipid syndrome or antiphospholipid antibody syndrome (APS or APLS), is an autoimmune, hypercoagulable state caused by the presence of antibodies directed against phospholipids.