Controversies in the Pharmacological Treatment of Uveitis

Current Pharmaceutical Design
Robert J Barry, Alastair K Denniston

Abstract

Uveitis is a term applied to a broad range of conditions characterized by intraocular inflammation. The pharmacological treatment of uveitis is controversial, with limited high-level evidence to inform most of the key treatment decisions that face the patient and clinician on a daily basis. In this review we identified twelve systematic reviews (including two Cochrane reviews) focused on key therapeutic questions in infectious and noninfectious uveitis. Our analysis of these reviews demonstrates the paucity of trial evidence available to inform these important clinical decisions. We consider the reasons for this, and look at the way forward for clinical trials in uveitis, so that we can move from controversy to clarity in the pharmacotherapy of uveitis.

Citations

Aug 21, 2016·Lancet·Alastair K Denniston, H Nida Sen
Feb 28, 2019·Ocular Immunology and Inflammation·Mohammad O TallouziAlastair K Denniston
Jul 30, 2020·BMJ Open Ophthalmology·Mohammad O TallouziJonathan M Mathers
Jan 31, 2021·Ophthalmology·Mohammad O TallouziUNKNOWN COSUMO Working Group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Ophthalmology Clinics
Jane S KimH Nida Sen
Documenta Ophthalmologica. Advances in Ophthalmology
H KLESS
Statistical Methods in Medical Research
Vance W Berger
Inflammatory Bowel Diseases
Brian G FeaganJohn K MacDonald
© 2021 Meta ULC. All rights reserved