Controversies in Topical Antibiotics Use with Intravitreal Injections

Current Pharmaceutical Design
Stephen G SchwartzAndrzej Grzybowski

Abstract

Endophthalmitis following intravitreal injection is uncommon. There are currently no randomized clinical trials evaluating the role of prophylactic topical antibiotics in this setting. Many large series have reported that topical antibiotics do not decrease, and may in fact increase the rate of endophthalmitis. The reason for this apparent paradoxical finding is unknown but may be due to changes in conjunctival flora due to repeated exposure to antibiotics. At this time, antiseptics (specifically povidone-iodine), rather than antibiotics, are preferred for the majority of patients undergoing intravitreal injections.

Citations

Mar 21, 2018·Asia-Pacific Journal of Ophthalmology·Taraprasad Das, Savitri Sharma
Dec 28, 2017·Asia-Pacific Journal of Ophthalmology·Andrzej Grzybowski, Magdalena Turczynowska
Oct 7, 2017·Current Opinion in Ophthalmology·Andrzej GrzybowskiWilliam G Myers
Feb 3, 2018·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Andrzej GrzybowskiUNKNOWN Euretina Board

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