PMID: 8950722Jan 1, 1996Paper

Controversies: synthetic or natural surfactant treatment for respiratory distress syndrome? The case for synthetic surfactant

Journal of Perinatal Medicine
A Whitelaw

Abstract

The choice of surfactant for prophylactic or "rescue" treatment of RDS is dependent on a number of different considerations: a) Randomised controlled trials have shown that natural and synthetic surfactants increase survival whether used prophylactically or as rescue. No statistically significant difference in mortality has been shown when the two types of surfactant have been compared in randomised trials. b) Possible adverse effects of surfactant treatment include: (i) Intraventricular haemorrhage (IVH). Two randomised trials of natural surfactant have shown a significant increase in IVH with natural surfactant treatment. In meta-analyses, IVH has not been significantly reduced despite decreased mortality. Acute changes in cerebral haemodynamics and EEG have been demonstrated following natural surfactant administration. These changes are less marked or absent with synthetic surfactant. (ii) The antigenicity of animal surfactant has not been shown to have clinical consequences. (iii) Prions are infectious particle (resistant to some sterilising techniques) which are responsible for slow encephalopathies, some of which have crossed species barriers. Contamination of bovine surfactant with prion particles from nervous tissue has...Continue Reading

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The Turkish Journal of Pediatrics
A D Milner
Journal of Perinatology : Official Journal of the California Perinatal Association
F Moya
European Journal of Pediatrics
R F Soll
Seminars in Perinatology
W Long
© 2021 Meta ULC. All rights reserved