Controversy: Noninvasive and invasive cortical stimulation show efficacy in treating stroke patients

Brain Stimulation
Friedhelm C HummelChristian Gerloff

Abstract

Stroke is the leading cause of disability in the adult population of western industrialized countries. Despite significant improvements of acute stroke care, two thirds of stroke survivors have to cope with persisting neurologic deficits. Adjuvant brain stimulation is a novel approach to improving the treatment of residual deficits after stroke. Transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), and epidural electrical stimulation have been used in first trials on small cohorts of stroke patients. Effect sizes in the order of 8% to 30% of functional improvement have been reported, but a publication bias toward presenting "promising" but not negative results is likely. Many questions regarding underlying mechanisms, optimal stimulation parameters, combination with other types of interventions, among others, are open. This review addresses six controversies related to the experimental application of brain stimulation techniques to stroke patients. Cortical stimulation after stroke will need to be individually tailored and a thorough patient stratification according to type and extent of clinical deficit, lesion location, lesion size, comorbidities, time in the recovery process, and perhaps al...Continue Reading

References

May 1, 1990·Stroke; a Journal of Cerebral Circulation·S L Wood-DauphineeS H Shapiro
Aug 17, 1990·Science·M B Calford, R Tweedale
Sep 1, 1984·Stroke; a Journal of Cerebral Circulation·S Wood-DauphineeB Mendelsohn
Feb 4, 1998·Electroencephalography and Clinical Neurophysiology·P CicinelliP M Rossini
Feb 25, 2000·Brain : a Journal of Neurology·K StefanJ Classen
Jul 24, 2002·Brain : a Journal of Neurology·Toshio ShimizuPaolo M Rossini
Jul 26, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Massimo GangitanoAlvaro Pascual-Leone
Oct 12, 2002·Proceedings of the National Academy of Sciences of the United States of America·Heidi Johansen-BergPaul M Matthews
Dec 13, 2002·Experimental Brain Research·Hartwig Roman Siebner, John Rothwell
Jan 16, 2003·Physiology & Behavior·Richard P Dum, Peter L Strick
Mar 4, 2003·Journal of Neurophysiology·Alexander WoltersJoseph Classen
May 10, 2003·Stroke; a Journal of Cerebral Circulation·Cinzia Calautti, Jean-Claude Baron
Aug 16, 2003·Stroke; a Journal of Cerebral Circulation·Pamela DuncanDallas Johnson
Aug 26, 2003·Brain : a Journal of Neurology·N S WardR S J Frackowiak
Oct 2, 2003·Annals of Neurology·Konrad J WerhahnLeonardo G Cohen
Dec 13, 2003·Neurological Research·G Campbell TeskeyNicole A Young
Dec 13, 2003·Neurological Research·Jeffrey A BrownMartin Weinand
Jan 9, 2004·Journal of Neurophysiology·Cathrin M BütefischLeonardo G Cohen
Jan 30, 2004·Brain : a Journal of Neurology·Esteban A FridmanLeonardo G Cohen
Mar 3, 2004·Annals of Neurology·Nagako MuraseLeonardo G Cohen
Apr 2, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hartwig R SiebnerJohn C Rothwell
May 1, 2004·Seminars in Speech and Language·Paula I MartinAlvaro Pascual-Leone
May 18, 2004·Experimental Brain Research·Young H Sohn, Mark Hallett
Jun 3, 2004·Annals of Neurology·Nick S WardRichard S J Frackowiak
Jun 17, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Michael A NitscheWalter Paulus
Nov 16, 2004·Current Opinion in Neurology·Nick S Ward
Jan 7, 2005·Brain : a Journal of Neurology·Friedhelm HummelLeonardo G Cohen
Jan 25, 2005·Neuron·Ying-Zu HuangJohn C Rothwell
Jan 28, 2005·Neurorehabilitation and Neural Repair·Friedhelm Hummel, Leonardo G Cohen
Feb 11, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Richard P Dum, Peter L Strick
Apr 22, 2005·Journal of Neurophysiology·Bernhard VollerMark Hallett
Jul 19, 2005·Annual Review of Neuroscience·Alvaro Pascual-LeoneLotfi B Merabet
Aug 9, 2005·NeuroImage·Julie DuqueLeonardo G Cohen
Sep 9, 2005·Neuroreport·Felipe FregniAlvaro Pascual-Leone

❮ Previous
Next ❯

Citations

Apr 18, 2013·Current Atherosclerosis Reports·Bruce H Dobkin, Andrew Dorsch
Aug 21, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Mark S George, Gary Aston-Jones
May 15, 2013·Aphasiology·Leora R CherneySteven L Small
Dec 6, 2011·Cerebral Cortex·Lynley V BradnamWinston D Byblow
Jan 18, 2013·Neural Plasticity·Naoyuki TakeuchiShin-Ichi Izumi
Dec 14, 2011·Neurophysiologie clinique = Clinical neurophysiology·J-P LefaucheurL Garcia-Larrea
Dec 20, 2013·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ela B Plow, Andre Machado
Jan 15, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Shuhei FujimotoSatoshi Tanaka
Sep 10, 2014·Experimental Brain Research·Kevin T JonesMarian E Berryhill
Sep 10, 2014·Nature Reviews. Neurology·Giovanni Di PinoVincenzo Di Lazzaro
Oct 28, 2010·Expert Review of Neurotherapeutics·Mark S George
Feb 7, 2016·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Kelsey A Potter-BakerEla B Plow
Apr 5, 2016·Annals of Clinical and Translational Neurology·Philipp KochFriedhelm C Hummel
Mar 24, 2016·Neural Plasticity·E B PlowA G Machado
Oct 24, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Jodie MarquezMark Parsons
Sep 1, 2015·Journal of the Neurological Sciences·Kelsey A Potter-BakerEla B Plow
Nov 3, 2015·Physical Medicine and Rehabilitation Clinics of North America·David A CunninghamEla B Plow
Mar 15, 2012·Developmental Psychobiology·Benjamin ThompsonRobert F Hess
Apr 10, 2015·Restorative Neurology and Neuroscience·Elisabetta LàdavasAndrea Serino
Sep 1, 2015·Journal of Neurology, Neurosurgery, and Psychiatry·Nyeonju KangJames H Cauraugh
May 6, 2014·Archives of Physical Medicine and Rehabilitation·Kristen M Triandafilou, Derek G Kamper
Jun 1, 2015·Brain Stimulation·Ilkka LaaksoAkimasa Hirata
Apr 9, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Milan B JelićSaša R Filipović
Jul 19, 2014·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jean-Pascal LefaucheurLuis Garcia-Larrea
Jun 13, 2012·Neuropharmacology·Robert SchulzFriedhelm C Hummel
May 3, 2016·Neurosurgical Focus·Tej D AzadGary K Steinberg
Jan 14, 2017·PM & R : the Journal of Injury, Function, and Rehabilitation·Raimund AlberBernhard A Sabel
Feb 22, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Cristina RussoFelipe Fregni
Dec 29, 2017·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Estelle Raffin, Friedhelm C Hummel
Aug 18, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Manus J DonahueJeroen Hendrikse
May 22, 2010·Stroke; a Journal of Cerebral Circulation·Suzanne J AckerleyWinston D Byblow
Sep 11, 2018·Pediatric Physical Therapy : the Official Publication of the Section on Pediatrics of the American Physical Therapy Association·Angela HamiltonJodie Marquez
Feb 26, 2010·Journal of Neurophysiology·François D RoyMonica A Gorassini
Jul 2, 2019·Brain : a Journal of Neurology·Martina CosciaFriedhelm C Hummel
Dec 21, 2019·Neurorehabilitation and Neural Repair·Estelle RaffinFriedhelm Christoph Hummel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.

Acute Stroke

A stroke occurs when blood supply to the brain is interrupted depriving the brain of oxygen and nutrients. This feed focuses cerebrovascular accidents including ischemic and paralytic stroke.

© 2021 Meta ULC. All rights reserved