Convection enhanced delivery of liposome encapsulated doxorubicin for brain tumour therapy

Journal of Controlled Release : Official Journal of the Controlled Release Society
Wenbo Zhan, Chi-Hwa Wang

Abstract

Convection enhanced delivery is promising to overcome the blood brain barrier. However, the treatment is less efficient in clinic due to the rapid elimination of small molecular drugs in brain tumours. In this study, numerical simulation is applied to investigate the convection enhanced delivery of liposome encapsulated doxorubicin under various conditions, based on a 3-D brain tumour model that is reconstructed from magnetic resonance images. Treatment efficacy is evaluated in terms of the tumour volume where the free doxorubicin concentration is above LD90. Simulation results denote that intracerebral infusion is effective in increasing the interstitial fluid velocity and inhibiting the fluid leakage from blood around the infusion site. Comparisons with direct doxorubicin infusion demonstrate the advantages of liposomes in enhancing the doxorubicin accumulation and penetration in the brain tumour. Delivery outcomes are determined by both the intratumoural environment and properties of therapeutic agents. The treatment efficacy can be improved by either increasing the liposome solution concentration and infusion rate, administrating liposomes in the tumour with normalised microvasculature density, or using liposomes with low v...Continue Reading

Citations

Jul 10, 2020·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Gustavo A OrozcoJosé J García
Dec 14, 2018·Pharmaceutics·Daniel Mihai TeleanuRaluca Ioana Teleanu
Nov 30, 2018·Journal of Clinical Medicine·Daniel Mihai TeleanuRaluca Ioana Teleanu
Oct 19, 2019·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Wenbo Zhan
Dec 17, 2020·Pharmaceutics·Jessica I GriffithWilliam F Elmquist
Aug 31, 2020·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ajay BhandariNiraj Sinha
Jul 13, 2021·Frontiers in Oncology·Farshad Moradi KashkooliArman Rahmim
Jan 19, 2022·Journal of Internal Medicine·Sneha RathiWilliam F Elmquist

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