Convection-enhanced distribution of large molecules in gray matter during interstitial drug infusion

Journal of Neurosurgery
D M LiebermanE H Oldfield

Abstract

Many novel experimental therapeutic agents, such as neurotrophic factors, enzymes, biological modifiers, and genetic vectors, do not readily cross the blood-brain barrier. An effective strategy to deliver these compounds to the central nervous system is required for their application in vivo. Under normal physiological conditions, brain interstitial fluid moves by both bulk flow (convection) and diffusion. It has recently been shown that interstitial infusion into the white matter can be used to increase bulk flow, produce interstitial convection, and efficiently and homogeneously deliver drugs to large regions of brain without significant functional or structural damage. In theory, even more uniform distribution is likely in gray matter. In the current study, four experiments were performed to examine if convection-enhanced delivery could be used to achieve regional distribution of large molecules in gray matter. First, the volume and consistency of anatomical distribution of 20 microliters of phaseolus vulgaris-leukoagglutinin (PHA-L; molecular weight (MW) 126 kD) after continuous high-flow microinfusion into the striatum of five rats over 200 minutes were determined using immunocytochemistry and quantified with image analysi...Continue Reading

References

Sep 1, 1992·Journal of Neurosurgery·K Ohata, A Marmarou
May 1, 1991·Trends in Neurosciences·H Thoenen
Sep 28, 1990·Science·R Langer
Jun 1, 1989·Neuron·Y A Barde
Jul 1, 1986·Annals of Internal Medicine·W M PardridgeH J Frank
Jan 1, 1988·Annals of the New York Academy of Sciences·J Fenstermacher, T Kaye
Feb 1, 1986·Journal of Pharmaceutical Sciences·P F Morrison, R L Dedrick
Oct 1, 1972·Behavioral Biology·A Routtenberg
May 1, 1984·The Journal of Surgical Research·W T ChanceJ E Fischer
Mar 1, 1982·Neurosurgery·J S Kroin, R D Penn
Mar 15, 1994·Proceedings of the National Academy of Sciences of the United States of America·R H BoboE H Oldfield
Mar 12, 1993·Science·R Stone
Oct 1, 1991·Journal of Applied Biomaterials : an Official Journal of the Society for Biomaterials·C J Damien, J R Parsons

❮ Previous
Next ❯

Citations

Aug 24, 2001·Brain Tumor Pathology·T WakabayashiY Kajita
Feb 13, 2009·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Yuichi TangeTadanori Tomita
Mar 7, 2012·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Junichi YoshimuraGeorge I Jallo
Jul 13, 2006·Annals of Biomedical Engineering·Malisa SarntinoranontThomas H Mareci
Sep 12, 2007·Annals of Biomedical Engineering·Xiaoming Chen, Malisa Sarntinoranont
Aug 3, 2011·Annals of Biomedical Engineering·Xiaoming ChenMalisa Sarntinoranont
Oct 8, 2011·Bulletin of Mathematical Biology·Joshua H SmithJosé Jaime García
Mar 20, 2002·Current Neurology and Neuroscience Reports·M S LesniakH Brem
Apr 9, 2002·Current Neurology and Neuroscience Reports·Dale F KraemerEdward A Neuwelt
Mar 1, 1996·Molecular Medicine Today·N J Abbott, I A Romero
Apr 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Michael A Rogawski
May 3, 2006·Molecular Therapy : the Journal of the American Society of Gene Therapy·Piotr HadaczekKrystof Bankiewicz
Apr 29, 2000·Pharmaceutical Science & Technology Today·J TemsamaniM Kaczorek
Jun 1, 2010·Neuro-oncology·Sandeep KunwarUNKNOWN PRECISE Study Group
Jun 7, 2000·Current Opinion in Oncology·R I Haroun, H Brem
Sep 4, 2003·The Cancer Journal·Ian F Parney, Susan M Chang
Aug 30, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Julia RousseauHélène Elleaume
Apr 12, 2008·Neuro-oncology·John H SampsonDarell D Bigner
Sep 10, 2011·International Journal of Nanomedicine·Enav Corem-SalkmonYael Mardor
Dec 22, 2009·Future Oncology·Dani S BidrosMichael A Vogelbaum
Apr 7, 2010·Journal of Neurosurgery. Pediatrics·Henrik GieseUlrich-W Thomale
Jul 3, 2009·Neurosurgical Focus·Pratik RohatgiParag G Patil
Sep 1, 2009·Journal of Neurosurgery·John D HeissRussell R Lonser
Dec 3, 2009·Journal of Neurosurgery. Pediatrics·Akihide KondoTadanori Tomita

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
antisense oligodeoxynucleotides

Software Mentioned

Image

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.