Convenient approach to polypeptide copolymers derived from native proteins

Biomacromolecules
Yuzhou WuTanja Weil

Abstract

A convenient approach for the synthesis of narrowly dispersed polypeptide copolymers of defined compositions is presented. The controlled denaturation of the proteins serum albumin and lysozyme followed by an in situ stabilization with polyethylene(oxide) chains yields polypeptide side chain copolymers of precisely defined backbone lengths as well as the presence of secondary structure elements. Supramolecular architectures are formed in solution because of the presence of hydrophobic and hydrophilic amino acids along the polypeptide main chain. Polypeptide copolymers reported herein reveal excellent solubility and stability in aqueous media and no significant cytotoxicity at relevant concentrations, and they can be degraded via proteolysis, which is very attractive for biomedical applications. This "semi-synthetic chemistry" approach is based on a novel and convenient concept for producing synthetic polypeptides from native protein resources, which complements traditional polypeptide synthesis and expression approaches and offers great opportunities for the preparation of diverse polypeptides with unique architectures.

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Citations

Oct 15, 2014·Chemical Communications : Chem Comm·Yuzhou WuTanja Weil
Feb 1, 2013·Macromolecular Rapid Communications·Seah Ling KuanTanja Weil
Dec 11, 2013·Macromolecular Rapid Communications·Dorothee E BorchmannMarcus Weck
Mar 20, 2015·Macromolecular Rapid Communications·Aydan DagMartina H Stenzel
May 31, 2016·Chembiochem : a European Journal of Chemical Biology·David PaleschTanja Weil
Jan 18, 2017·Journal of the American Chemical Society·Sabyasachi ChakraborttyTanja Weil
Feb 24, 2017·Scientific Reports·Miguel SisonTheo Lasser
Mar 11, 2017·Biomaterials Science·Sabyasachi ChakraborttyTanja Weil
May 18, 2019·Chemical Communications : Chem Comm·Xueli ZhuJian-Hui Jiang
Dec 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Hongxu LuMartina H Stenzel
Mar 21, 2016·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Yanyan JiangMartina H Stenzel
Oct 31, 2014·Accounts of Chemical Research·David Yuen Wah NgTanja Weil
Dec 13, 2019·Journal of the American Chemical Society·Chaojian ChenTanja Weil

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