Convenient synthesis of novel geiparvarin analogs with potential anti-cancer activity via click chemistry

European Journal of Medicinal Chemistry
Yikai ZhangKe Li

Abstract

Based on the advantages of natural products in new anti-cancer drug development, we synthesized a series of novel benzopyran-4-one derivatives and evaluated their in vitro anti-cancer activities. The bioassays showed that the majority of the resultant compounds exerted anti-tumor effect against six human cancer cell lines to various extents, which supported the rationale of the design. Compound 5s exhibited highest potency of all the synthesized compounds.

References

Aug 13, 2005·Cancer Chemotherapy and Pharmacology·Lori J Pobst, Matthew M Ames

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Citations

Apr 3, 2014·European Journal of Medicinal Chemistry·Rangappa S KeriR Geetha Balakrishna
Nov 19, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ravil N KhaybullinXin Qi
Nov 28, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mohammad Bagher MajnooniAnupam Bishayee
Jul 28, 2020·Cancers·Esra Küpeli AkkolRaffaele Capasso
Feb 22, 2014·Chemical Reviews·Alexandra GasparFernanda Borges
Sep 15, 2021·Chemical Biology & Drug Design·Vaishali M PatilVijay Masand

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