Abstract
The regulation of immune responses occurring during Bacillus Calmette-Guerin (BCG) therapy need to be better scrutinized in order to identify new targetable pathways for non-muscle invasive bladder cancer treatment. Immunoregulatory mechanisms have emerged as key players in various cancers. While T lymphocytes are crucial for the control of tumor growth, they often include regulatory subsets known to restrain their anti-tumor activity. In this prospective study, we assessed conventional regulatory T cells (cTregs) and PD-L1-expressing CD4 T cells (PD-L1+ Tregs) levels in blood and urine of urothelial cancer (UCa) patients undergoing BCG treatment. Local cTregs were found at higher frequencies than their counterpart in the periphery and induced by bladder tumor cells in vitro. Interestingly, while circulating PD-L1+ Tregs were hardly detectable in the blood of healthy donors and UCa patients, substantial levels were found in patients' urine. In vitro experiments suggested that BCG infection of urothelial cells could induce PD-L1+ Tregs, partially via an interferon-β-mediated mechanism. Of note, high level of Tregs in urine was associated with rapid recurrence following BCG therapy. Our findings demonstrate that T lymphocytes rec...Continue Reading
Citations
Nov 23, 2019·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Emilie Stavnsbjerg LarsenIsik Somuncu Johansen
Dec 4, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Eiji KikuchiKazuhiro Matsumoto
Jul 20, 2019·BMJ Open·Marcus L JamilShaheen Alanee
Sep 15, 2020·Science China. Life Sciences·Zhangsong WuSong Wu
Jan 5, 2020·World Journal of Urology·Ahmet Murat AydinCenk Y Bilen
Apr 16, 2019·Frontiers in Immunology·Perrine BohnerLaurent Derré
May 19, 2019·The Journal of Pathology·Dongkui SongYong-Jie Lu
Sep 11, 2019·Nature Reviews. Urology·Anna K SchneiderLaurent Derré
Aug 11, 2018·Nature Reviews. Urology·Annette Fenner
Apr 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Takahiro KamadaHiroyoshi Nishikawa
Apr 3, 2020·Current Opinion in Urology·José D SubielaJoan Palou
Sep 15, 2020·Oncoimmunology·Wenlong ZhongTianxin Lin
Sep 6, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claus AagaardRasmus Mortensen
Dec 3, 2020·Urologic Oncology·John P SfakianosAmir Horowitz
Jan 30, 2021·Life Sciences·Vahid KarpishehFarhad Jadidi-Niaragh
Jan 9, 2021·Immunobiology·Aaron J Moulson, Yossef Av-Gay
Dec 4, 2020·Nature Reviews. Cancer·Linda TranDan Theodorescu
Oct 6, 2020·Actas urologicas españolas·M Álvarez-MaestroJ M Fernández-Gómez
Nov 24, 2019·The Urologic Clinics of North America·Lauren Folgosa CooleyJoshua J Meeks
Apr 4, 2021·Cancers·Omar M IbrahimPawel Kalinski
Jun 2, 2021·The Journal of Clinical Investigation·Alok K SinghWilliam R Bishai
Jul 11, 2021·Scientific Reports·Georgi TosevStefan Duensing
Nov 4, 2021·The Journal of Pathology·Kara A LombardoTrinity J Bivalacqua
Apr 4, 2019·Oncology Research·Caiqi LiuJinfeng Liu