Conventional and quantitative liver function tests after hepatic transplantation: a prospective long-term follow-up

Transplant International : Official Journal of the European Society for Organ Transplantation
J von SchönfeldF W Eigler

Abstract

In long-term survivors of liver transplantation, hepatic function is obviously of vital importance. Therefore, we prospectively performed conventional and quantitative liver function tests in patients who had survived a first transplantation for at least 4 years. Compared to 6 months after transplantation, serum bilirubin concentration and gamma GT activity were significantly lower after 3, 4, and 5 years (bilirubin 1.2 +/- 0.2 mg/dl at 6 months vs 1.0 +/- 0.1, 1.0 +/- 0.2, and 0.8 +/- 0.1 mg/dl respectively; gamma GT 106 +/- 0 33 U/l at 6 months vs 56 +/- 17, 67 +/- 35, 39 +/- 10 U/l respectively). At these points in time, blood levels of cyclosporin A were also significantly lower. Other parameters of liver cell function and liver cell integrity (AP, AST, ALT, GLDH, total protein, thromboplastin time, partial thromboplastin time) were unchanged over time. Serial quantitative liver function tests (indocyanine green half-life, galactose elimination capacity, lidocaine half-life, and MEGX formation) also remained stable. Thus, we conclude that hepatic function remains stable in long-term survivors of liver transplantation for at least several years.

References

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Citations

Apr 2, 2010·Journal of Korean Medical Science·Mei Lan CuiSung Su Yun
Feb 17, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Christoph JochumGuido Gerken
Aug 19, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Erika Martínez-LópezArturo Panduro
Dec 21, 2000·Journal of Clinical Pharmacy and Therapeutics·E TanakaH Yasuhara

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