Conventional cervical cytologic smears vs. ThinPrep smears. A paired comparison study on cervical cytology

Acta Cytologica
A FerenczyT C Wright

Abstract

To compare the time required for evaluation, the diagnostic accuracy and quality of conventional glass slide smears vs. ThinPrep smears in 365 women. Both smears were obtained at the same time using the Accellon Combi cervical biosampler. Histology served as the diagnostic "gold standard." The average screening time was 1 minute, 23 seconds, shorter per smear with the ThinPrep method as compared to the conventional glass slide (P < .001). Direct diagnostic agreement between the two smear methods was obtained in 311 of 364 evaluable smears (85.4%, kappa = .63). Despite the relatively high rate of "adequate but limited by absence of transformation zone components" observed with the ThinPrep method, the sensitivity and specificity of the ThinPrep method was slightly greater but not statistically significantly different than the conventional technique, irrespective of the disease categories (low and high grade squamous intraepithelial lesion and invasive cancer). The shorter time required to screen ThinPrep smears compared to conventional smears in this study was not sufficiently important to offset the current unit price for preparing ThinPrep smears.

Citations

Jan 4, 2012·Archives of Gynecology and Obstetrics·Aydın KöşüşHasan Kafalı
Oct 16, 2004·Current Oncology Reports·Dorothy J WileyKristina Morgan
Apr 5, 2003·BMJ : British Medical Journal·Joël CosteUNKNOWN French Society of Clinical Cytology Study Group
Jan 1, 2008·Obstetrics and Gynecology·Marc ArbynJohan Bulten
Oct 18, 2005·BJOG : an International Journal of Obstetrics and Gynaecology·T HusseinH C Kitchener
Oct 12, 2005·International Journal of Cancer. Journal International Du Cancer·Johannes BerkhofChris J L M Meijer
Jan 31, 2008·Diagnostic Cytopathology·Yoo-Duk ChoiChang-Soo Park
Mar 24, 2007·BJOG : an International Journal of Obstetrics and Gynaecology·V M H CoupéC J L M Meijer
Oct 28, 2003·Cancer·Paul J J M KlinkhamerAntonius G J M Hanselaar
Oct 3, 2002·Diagnostic Cytopathology·Estelle MéréaJoël Coste
Aug 19, 2007·Diagnostic Cytopathology·Elizabeth DaveyAnnabelle Farnsworth
Feb 13, 2001·Diagnostic Cytopathology·J F NasutiP K Gupta
May 4, 1999·Seminars in Surgical Oncology·H N Nguyen, S R Nordqvist
Jan 10, 2008·Archives of Pathology & Laboratory Medicine·Stephen S RaabJoseph A Tworek
Jan 2, 2003·Obstetrics and Gynecology Clinics of North America·Juan C Felix, Charles Amezcua

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