PMID: 2511562Jan 1, 1989Paper

Conventional chemotherapeutic agents combined with DMSO or DFMO in treatment of rat prostate carcinoma

The Prostate
D D MickeyK Foulkes

Abstract

Chemotherapy for prostatic carcinoma is usually reserved for those patients who have failed conventional therapy. These patients generally are in poor health and tolerate chemotherapy poorly. If doses of conventional agents could be decreased without altering cytotoxic activity, then conventional chemotherapy could become an attractive treatment modality. Dimethylsulfoxide and difluoromethylornithine have been shown to induce differentiation in some tumor systems. Growth alteration effects of these two agents were investigated individually and in association with conventional chemotherapeutic agents cyclophosphamide, cisplatin, and fluorouracil in an experimental prostatic cancer model. Copenhagen rats had subcutaneous tumors induced by injections of cells cultured in vitro from a subline of the Dunning rat prostatic tumor, MAT LyLu. Treatment with chemotherapeutic agents individually and associated with differentiation agents was initiated when tumors were palpable. Tumor growth rates and rat body weights were monitored in all groups. The differentiation agents used singly were not able to retard significantly tumor growth rates. In higher doses, each conventional agent used singly significantly retarded tumor growth. Used in ...Continue Reading

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Citations

Jan 1, 1996·Pathology Oncology Research : POR·Kenneth V HonnDavid P Wood
Aug 17, 1996·Mutation Research·M A JacksonM D Waters
Apr 29, 1998·Comprehensive Therapy·L Kuritzky
Jan 1, 1997·International Journal of Radiation Oncology, Biology, Physics·L T YonemotoJ M Slater
Aug 1, 1991·Annals of Medicine·J JänneP Leinonen
Oct 1, 1995·Metabolism: Clinical and Experimental·T Le BriconV E Baracos
Jan 28, 2017·Future Oncology·George A AlexiouAthanassios P Kyritsis

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