PMID: 8938815Oct 1, 1996Paper

Conventional MRI volumetric measures of parietal and insular cortex in Alzheimer's disease

Progress in Neuro-psychopharmacology & Biological Psychiatry
Anne L FoundasB Seltzer

Abstract

1. Although volumetric Magnetic Resonance Imaging (MRI) studies suggest regional cortical atrophy in Alzheimer's disease (AD), only one prior study documented atrophy of the parietal and insular cortex (Foundas et al, 1993). 2. To further investigate this potential early marker of AD, the authors computed volumetric measures of these regions on conventional axial MRI sections in 25 patients with mild to moderate "probable AD" and 25 age- and sex-matched controls. 3. Regions of interest (ROIs) from T1-axial images (5mm) were scanned into a PCX format (400 dots/inch) and volumes of CSF fluid were calculated using an Autocad program. 4. AD patients showed significant parietal (p < .01) and insular (p < .002) atrophy as compared to controls. 5. These findings suggest that atrophy of the parietal and insular cortex may occur early in AD patients, and that certain quantitative measures on conventional MRI accurately discriminate AD patients from controls.

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Citations

Sep 21, 2001·Journal of Geriatric Psychiatry and Neurology·Y Y HsuM W Weiner
Jul 18, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Arthur MikhnoRamin V Parsey
Aug 8, 2009·Journal of Psychiatric Research·Jeremy D CohenAnne L Foundas
Apr 25, 2007·Magnetic Resonance Imaging·Marco Bozzali, Andrea Cherubini
Oct 22, 1998·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·A L FoundasC A Browning
Jul 12, 2020·American Journal of Speech-language Pathology·Nicole M Rogus-Pulia, Emily K Plowman

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