Convergence of the proteomic pattern in cancer

Bioinformatics
Ute MüllerFerdinand von Eggeling

Abstract

On the histological level the differentiation of normal epithelial tissues is well known. The phenomenon of dedifferentiation, which occurs as cells develop towards malignancy is also well described. To identify an epithelial tumor-specific proteomic profile as well as to measure the proximities between we used data from tumor tissue and adjacent normal tissue microdissected from head and neck and colon cancer samples which were analyzed using ProteinChip technology and performed a bioinformatic meta-analysis on the resulting four complex datasets. All four groups could be identified based on their proteomic signatures and the tumor tissues were found to be more similar to one another than to the normal epithelial tissue from which they progressed. This study shows at the proteomic level that changes in the histological features of tumors as compared to the tissues from which they arise are reflected in the convergence of proteomic pattern during the development to cancer.

References

Jun 18, 2004·Emerging Infectious Diseases·Yukiko WagatsumaMahbubur Rahman
Jun 19, 2004·Cancer Research·Christian MelleFerdinand von Eggeling
Jul 15, 2004·Annals of the New York Academy of Sciences·Lori L WilsonDave S B Hoon
Sep 9, 2005·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Günther ErnstFerdinand von Eggeling
Jan 1, 2006·Mathematical Biosciences and Engineering : MBE·Junling Ma, Zhien Ma

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Citations

Jun 25, 2008·Molecular & Cellular Proteomics : MCP·Suresh Mathivanan, Akhilesh Pandey
Sep 12, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Stella SunJohn M Luk
Nov 15, 2007·International Journal of Cancer. Journal International Du Cancer·DunFa PengWael El-Rifai
Jul 20, 2007·Proteomics·Ferdinand von EggelingGünther Ernst

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