Convergence on chromatin of non-genomic and genomic pathways of hormone signaling

The Journal of Steroid Biochemistry and Molecular Biology
Guillermo P VicentMiguel Beato

Abstract

Gene regulation by steroid hormones involves genomic and non-genomic signaling pathways and the relationship between these two pathways is unknown. Genomic actions are often mediated by binding of the ligand-activated hormone receptors to hormone responsive elements (HREs) followed by recruitment of co-regulators, remodeling of chromatin and formation of the transcription initiation complex. The non-genomic effects of steroid hormones involve the rapid and transient activation of several kinase cascades often mediated by a subpopulation of "nuclear" receptors located in the cytoplasmic side of the cell membrane. The progesterone effect on breast cancer cell proliferation involves activation of the Src/Ras/Erk cascade mediated by a specific interaction between two domains of the N-terminal half of PR and the ligand-binding domain of ERalpha. Unexpectedly, selective inhibition of Erk, or its target kinase Msk1, interferes with chromatin remodeling and blocks MMTV transcriptional activation. A complex of activated PR, Erk and Msk1 is recruited to promoter already 5 min after hormone treatment and phosphorylates histone H3 at serine 10, leading to displacement of HP1gamma, as a requisite for recruitment of Src1, chromatin remodelin...Continue Reading

References

Jan 25, 1992·Nucleic Acids Research·E H BresnickG L Hager
Jan 30, 2003·The EMBO Journal·Ronald KoopMiguel Beato
Jun 28, 2003·FEBS Letters·Alison L Clayton, Louis C Mahadevan
Nov 5, 2004·Molecular Cell·Guillermo P VicentMiguel Beato
Feb 8, 2005·Molecular Endocrinology·Linda Björnström, Maria Sjöberg

❮ Previous
Next ❯

Citations

Sep 29, 2011·Journal of Molecular Evolution·Ryoiti Kiyama, Yuko Wada-Kiyama
Feb 18, 2011·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Beatriz Pérez-CadahíaJames R Davie
Jan 8, 2009·Journal of Cellular Physiology·Geneviève P DelcuveJames R Davie
Nov 10, 2009·Advances in Enzyme Regulation·James R DavieGeneviève P Delcuve
Jan 21, 2011·Biology of Reproduction·Griselda VallejoPatricia Saragüeta
Jan 19, 2012·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Shannon HealyJames R Davie
May 21, 2010·Molecular Endocrinology·Guillermo P VicentMiguel Beato
Jul 8, 2009·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Yan LiRenny T Franceschi
Oct 17, 2019·World Journal of Stem Cells·Pia GiovannelliGabriella Castoria

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.