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Convergent adaptation of human lactase persistence in Africa and Europe

Nature Genetics

Jan 1, 2007

Sarah A. TishkoffPanos G Deloukas

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Abstract

A SNP in the gene encoding lactase (LCT) (C/T-13910) is associated with the ability to digest milk as adults (lactase persistence) in Europeans, but the genetic basis of lactase persistence in Africans was previously unknown. We conducted a genotype-phenotype association study in 470 Ta...read more

Mentioned in this Paper

Genetic Equilibrium
Single Nucleotide Polymorphism
Lactase
Lactase Persistence
Selection, Genetic
EAF2 gene
Phenotype Determination
Caco-2 Cells
Promoter
Evolution, Molecular
82
14
3
1146
1
4
Paper Details
References
  • References37
  • Citations456
12345...

Convergent adaptation of human lactase persistence in Africa and Europe

Nature Genetics

Jan 1, 2007

Sarah A. TishkoffPanos G Deloukas

PMID: 17159977

DOI: 10.1038/ng1946

Abstract

A SNP in the gene encoding lactase (LCT) (C/T-13910) is associated with the ability to digest milk as adults (lactase persistence) in Europeans, but the genetic basis of lactase persistence in Africans was previously unknown. We conducted a genotype-phenotype association study in 470 Ta...read more

Mentioned in this Paper

Genetic Equilibrium
Single Nucleotide Polymorphism
Lactase
Lactase Persistence
Selection, Genetic
82
14
3
1146
1
4

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Paper Details
References
  • References37
  • Citations456
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