Convergent Balancing Selection on an Antimicrobial Peptide in Drosophila

Current Biology : CB
Robert L UncklessBrian P Lazzaro

Abstract

Genes of the immune system often evolve rapidly and adaptively, presumably driven by antagonistic interactions with pathogens [1-4]. Those genes encoding secreted antimicrobial peptides (AMPs), however, have failed to exhibit conventional signatures of strong adaptive evolution, especially in arthropods (e.g., [5, 6]) and often segregate for null alleles and gene deletions [3, 4, 7, 8]. Furthermore, quantitative genetic studies have failed to associate naturally occurring polymorphism in AMP genes with variation in resistance to infection [9-11]. Both the lack of signatures of positive selection in AMPs and lack of association between genotype and immune phenotypes have yielded an interpretation that AMP genes evolve under relaxed evolutionary constraint, with enough functional redundancy that variation in, or even loss of, any particular peptide would have little effect on overall resistance [12, 13]. In stark contrast to the current paradigm, we identified a naturally occurring amino acid polymorphism in the AMP Diptericin that is highly predictive of resistance to bacterial infection in Drosophila melanogaster [13]. The identical amino acid polymorphism arose in parallel in the sister species D. simulans, by independent muta...Continue Reading

References

Mar 20, 2004·Science·Brian P LazzaroAndrew G Clark
Aug 20, 2004·Molecular Biology and Evolution·Mark S Bulmer, Ross H Crozier
Feb 8, 2005·Journal of Molecular Evolution·Humberto QuesadaMontserrat Aguadé
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Nov 8, 2007·Nature Genetics·Timothy B SacktonAndrew G Clark
Apr 18, 2008·BMC Evolutionary Biology·Edward J Hollox, John A L Armour
Jun 17, 2008·Current Opinion in Microbiology·Brian P Lazzaro
Sep 19, 2008·Molecular Biology and Evolution·Jacob A Tennessen, Michael S Blouin
Jan 1, 2008·Cytogenetic and Genome Research·E J Hollox
Oct 24, 2009·PLoS Genetics·Darren J ObbardFrancis M Jiggins
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Mar 13, 2015·PLoS Genetics·Robert L UncklessBrian P Lazzaro

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Citations

May 11, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Robert L Unckless, Brian P Lazzaro
Oct 26, 2016·BMC Evolutionary Biology·Mark A HansonSteve J Perlman
Mar 10, 2018·Viruses·William H PalmerRonald P van Rij
Apr 19, 2018·Evolution; International Journal of Organic Evolution·Felix Zajitschek, Tim Connallon
Oct 9, 2019·Proceedings of the National Academy of Sciences of the United States of America·Mohammad A Siddiq, Joseph W Thornton
Aug 29, 2019·G3 : Genes - Genomes - Genetics·Tom Hill, Robert L Unckless
Sep 19, 2019·Proceedings. Biological Sciences·Jenna Kay Lea, Robert L Unckless
Nov 7, 2016·Genetics·Angela M EarlyAndrew G Clark
May 2, 2020·Science·Brian P LazzaroJens Rolff
Aug 30, 2020·Nature Reviews. Genetics·Dieter Ebert, Peter D Fields
May 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Lin KangPawel Michalak
Oct 28, 2019·PloS One·Moria Cairns ChambersBrian P Lazzaro
Jan 15, 2017·BMC Evolutionary Biology·Myriam CrozeStephan Hutter
May 20, 2020·Frontiers in Immunology·Marco GerdolDelphine Destoumieux-Garzón
Sep 11, 2019·Genome Biology and Evolution·Joanne R ChapmanRobert L Unckless
Feb 2, 2021·Chemical Reviews·Jasmin PortelinhaAlfredo M Angeles-Boza
Dec 14, 2019·Current Opinion in Immunology·Mark Austin Hanson, Bruno Lemaitre
Aug 26, 2021·PLoS Pathogens·Mark Austin HansonBruno Lemaitre
Aug 29, 2021·Developmental and Comparative Immunology·Arun Prakash, Imroze Khan

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