Abstract
Genes of the immune system often evolve rapidly and adaptively, presumably driven by antagonistic interactions with pathogens [1-4]. Those genes encoding secreted antimicrobial peptides (AMPs), however, have failed to exhibit conventional signatures of strong adaptive evolution, especially in arthropods (e.g., [5, 6]) and often segregate for null alleles and gene deletions [3, 4, 7, 8]. Furthermore, quantitative genetic studies have failed to associate naturally occurring polymorphism in AMP genes with variation in resistance to infection [9-11]. Both the lack of signatures of positive selection in AMPs and lack of association between genotype and immune phenotypes have yielded an interpretation that AMP genes evolve under relaxed evolutionary constraint, with enough functional redundancy that variation in, or even loss of, any particular peptide would have little effect on overall resistance [12, 13]. In stark contrast to the current paradigm, we identified a naturally occurring amino acid polymorphism in the AMP Diptericin that is highly predictive of resistance to bacterial infection in Drosophila melanogaster [13]. The identical amino acid polymorphism arose in parallel in the sister species D. simulans, by independent muta...Continue Reading
References
Mar 20, 2004·Science·Brian P LazzaroAndrew G Clark
Aug 20, 2004·Molecular Biology and Evolution·Mark S Bulmer, Ross H Crozier
Feb 8, 2005·Journal of Molecular Evolution·Humberto QuesadaMontserrat Aguadé
May 5, 2005·PLoS Biology·Rasmus NielsenMichele Cargill
Sep 15, 2005·Genetics·Francis M Jiggins, Kang-Wook Kim
Nov 30, 2005·Journal of Evolutionary Biology·J A Tennessen
May 10, 2006·PLoS Genetics·Deborah Charlesworth
Aug 5, 2006·Genetics·Brian P LazzaroAndrew G Clark
Feb 8, 2007·Proceedings of the National Academy of Sciences of the United States of America·Joshua A ShapiroChung-I Wu
Mar 29, 2007·Heredity·L WilfertP Schmid-Hempel
Aug 28, 2007·Genetics·Kevin R Thornton
Nov 8, 2007·Nature Genetics·Timothy B SacktonAndrew G Clark
Apr 18, 2008·BMC Evolutionary Biology·Edward J Hollox, John A L Armour
Jun 17, 2008·Current Opinion in Microbiology·Brian P Lazzaro
Sep 19, 2008·Molecular Biology and Evolution·Jacob A Tennessen, Michael S Blouin
Feb 11, 2009·Nature Reviews. Genetics·Brian Charlesworth
Jan 1, 2008·Cytogenetic and Genome Research·E J Hollox
Oct 24, 2009·PLoS Genetics·Darren J ObbardFrancis M Jiggins
Jan 13, 2010·PLoS Genetics·Timothy B SacktonAndrew G Clark
Oct 20, 2010·Peptides·Enrico König, Olaf R P Bininda-Emonds
Jun 17, 2011·Molecular Ecology Resources·O Hellgren, B C Sheldon
Jun 12, 2012·Molecular Biology and Evolution·Darren J ObbardFrancis M Jiggins
Oct 12, 2012·Genome Research·Viola NolteChristian Schlötterer
Oct 17, 2012·PLoS Genetics·Josep M ComeronSamuel Bailin
Jan 17, 2014·PeerJ·Arun S Seetharam, Gary W Stuart
May 9, 2014·Molecular Ecology·Célia C GossetNicolas Bierne
Aug 22, 2014·PLoS Genetics·Michael DeGiorgioRasmus Nielsen
Nov 19, 2014·Evolution; International Journal of Organic Evolution·Ziyue GaoGuy Sella
Mar 13, 2015·PLoS Genetics·Robert L UncklessBrian P Lazzaro
Jun 4, 2015·PeerJ·Katrín Halldórsdóttir, Einar Árnason
Citations
May 11, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Robert L Unckless, Brian P Lazzaro
Oct 26, 2016·BMC Evolutionary Biology·Mark A HansonSteve J Perlman
Jan 19, 2017·Molecular Ecology·Virginia M Howick, Brian P Lazzaro
Mar 10, 2018·Viruses·William H PalmerRonald P van Rij
Apr 19, 2018·Evolution; International Journal of Organic Evolution·Felix Zajitschek, Tim Connallon
May 18, 2018·Molecular Ecology·Naomi L P KeehnenChristopher W Wheat
Feb 26, 2019·ELife·Mark Austin HansonBruno Lemaitre
Oct 9, 2019·Proceedings of the National Academy of Sciences of the United States of America·Mohammad A Siddiq, Joseph W Thornton
Aug 29, 2019·G3 : Genes - Genomes - Genetics·Tom Hill, Robert L Unckless
Sep 19, 2019·Proceedings. Biological Sciences·Jenna Kay Lea, Robert L Unckless
May 7, 2020·Molecular Ecology·Max LundbergLars Råberg
Nov 7, 2016·Genetics·Angela M EarlyAndrew G Clark
Apr 23, 2017·Scientific Reports·Ottavia RomoliFederica Sandrelli
May 5, 2017·Scientific Reports·Claire PapotAurélie Tasiemski
May 2, 2020·Science·Brian P LazzaroJens Rolff
Aug 30, 2020·Nature Reviews. Genetics·Dieter Ebert, Peter D Fields
Sep 6, 2020·Pharmaceutics·Viorica PatruleaOlivier Jordan
Jan 13, 2018·AMB Express·Shi-Huo LiuJin-Jun Wang
May 28, 2019·Proceedings of the National Academy of Sciences of the United States of America·Lin KangPawel Michalak
Nov 30, 2019·Frontiers in Immunology·Mark A HansonRobert L Unckless
Oct 28, 2019·PloS One·Moria Cairns ChambersBrian P Lazzaro
Aug 9, 2020·Frontiers in Immunology·Simon Le BloaAurélie Tasiemski
Jan 15, 2017·BMC Evolutionary Biology·Myriam CrozeStephan Hutter
May 20, 2020·Frontiers in Immunology·Marco GerdolDelphine Destoumieux-Garzón
Jun 21, 2017·Genetics·Chuan CaoFrancis M Jiggins
Sep 11, 2019·Genome Biology and Evolution·Joanne R ChapmanRobert L Unckless
Feb 27, 2020·Genes·Joanne R ChapmanRobert L Unckless
Jan 21, 2021·Archives of Microbiology·Lin ChenYunpeng Liu
Feb 2, 2021·Chemical Reviews·Jasmin PortelinhaAlfredo M Angeles-Boza
Dec 14, 2019·Current Opinion in Immunology·Mark Austin Hanson, Bruno Lemaitre
Dec 16, 2020·Antibiotics·Aneta NowakiewiczŁukasz Matuszewski
Feb 19, 2021·G3 : Genes - Genomes - Genetics·Tom HillRobert L Unckless
Apr 8, 2021·MSystems·Karissa L CrossSeth R Bordenstein
Jul 11, 2021·Molecular Ecology·Wen-Hao TanJames R Walters
Aug 26, 2021·PLoS Pathogens·Mark Austin HansonBruno Lemaitre
Aug 29, 2021·Developmental and Comparative Immunology·Arun Prakash, Imroze Khan