Convergent effects of a functional C3 variant on brain atrophy, demyelination, and cognitive impairment in multiple sclerosis

Multiple Sclerosis : Clinical and Laboratory Research
Tina RoostaeiMohammad Ali Sahraian

Abstract

Complement system activation products are present in areas of neuroinflammation, demyelination, and neurodegeneration in brains of patients with multiple sclerosis (MS). C3 is a central element in the activation of complement cascades. A common coding variant in the C3 gene (rs2230199, C3R102G) affects C3 activity. To assess the effects of rs2230199 on MS severity using clinical, cognitive, and imaging measures. In total, 161 relapse-onset MS patients (Expanded Disability Status Scale (EDSS) ≤ 6) underwent physical assessments, cognitive tests (Paced Auditory Serial Addition Test (PASAT), Symbol Digit Modalities Test (SDMT), and California Verbal Learning Test (CVLT)), and magnetic resonance imaging (MRI). Lesion volumes were quantified semi-automatically. Voxel-wise analyses were performed to assess the effects of rs2230199 genotype on gray matter (GM) atrophy ( n = 155), white matter (WM) fractional anisotropy (FA; n = 105), and WM magnetization transfer ratio (MTR; n = 90). While rs2230199 minor-allele dosage (C3-102G) showed no significant effect on EDSS and Multiple Sclerosis Functional Composite (MSFC), it was associated with worse cognitive performance ( p = 0.02), lower brain parenchymal fraction ( p = 0.003), and highe...Continue Reading

References

Jun 22, 2000·NeuroImage·J Ashburner, K J Friston
Nov 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·S NatafS R Barnum
Nov 15, 2001·Annals of Neurology·J W PrineasB P Morgan
Mar 18, 2005·Annual Review of Immunology·Mireia Sospedra, Roland Martin
Apr 21, 2006·NeuroImage·Stephen M SmithTimothy E J Behrens
Feb 14, 2007·Multiple Sclerosis : Clinical and Laboratory Research·B A ParmenterR H B Benedict
Dec 18, 2007·Cell·Beth StevensBen A Barres
May 22, 2008·Brain Pathology·Dimitrios PapadopoulosRichard Reynolds
Feb 6, 2009·Annals of Neurology·Michael H BarnettJohn W Prineas
Jun 16, 2009·Journal of Neuropathology and Experimental Neurology·Marco VercellinoPaola Cavalla
Apr 28, 2010·Brain : a Journal of Neurology·Gillian IngramBryan Paul Morgan
May 11, 2011·Proceedings of the National Academy of Sciences of the United States of America·Meike HeurichClaire L Harris
Jan 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Valeria RamagliaB Paul Morgan
Mar 19, 2014·Nature Reviews. Neurology·V Hugh Perry, Clive Holmes
Jun 3, 2014·Acta Neuropathologica Communications·Gillian IngramB Paul Morgan
Dec 10, 2014·The Journal of Biological Chemistry·Elizabeth RodriguezStephen J Perkins
Jan 22, 2015·Nature·Derrek P HibarSarah E Medland
Mar 3, 2015·Annals of Neurology·Iliana MichailidouValeria Ramaglia
Jun 16, 2015·NeuroImage·Anderson M WinklerStephen M Smith
Sep 25, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Qiaoqiao ShiCynthia A Lemere
Nov 4, 2015·Nature Reviews. Neurology·Christian EnzingerUNKNOWN MAGNIMS study group
Apr 9, 2016·Current Opinion in Neurology·Marloes HagensFrederik Barkhof
Aug 26, 2016·Proceedings of the National Academy of Sciences of the United States of America·Won-Suk ChungBen A Barres
Jan 18, 2017·Nature Communications·Derrek P HibarM Arfan Ikram

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Citations

Jul 11, 2019·Brain : a Journal of Neurology·Kathryn C FitzgeraldPeter A Calabresi
Aug 14, 2020·Immunological Investigations·Leia SenaFabiana Antunes Andrade
Dec 12, 2018·Frontiers in Cellular Neuroscience·Ciro De LucaMichele Papa
Oct 30, 2020·Pharmaceuticals·Maria GavriilakiEleni Gavriilaki
Nov 30, 2021·Experimental Biology and Medicine·Evans RaballahDouglas J Perkins

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