Convergent Metabotropic Signaling Pathways Inhibit SK Channels to Promote Synaptic Plasticity in the Hippocampus

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Cezar M TigaretJack R Mellor

Abstract

Hebbian synaptic plasticity at hippocampal Schaffer collateral synapses is tightly regulated by postsynaptic small conductance (SK) channels that restrict NMDA receptor activity. SK channels are themselves modulated by G-protein-coupled signaling pathways, but it is not clear under what conditions these are activated to enable synaptic plasticity. Here, we show that muscarinic M1 receptor (M1R) and type 1 metabotropic glutamate receptor (mGluR1) signaling pathways, which are known to inhibit SK channels and thereby disinhibit NMDA receptors, converge to facilitate spine calcium transients during the induction of long-term potentiation (LTP) at hippocampal Schaffer collateral synapses onto CA1 pyramidal neurons of male rats. Furthermore, mGluR1 activation is required for LTP induced by reactivated place-cell firing patterns that occur in sharp-wave ripple events during rest or sleep. In contrast, M1R activation is required for LTP induced by place-cell firing patterns during exploration. Thus, we describe a common mechanism that enables synaptic plasticity during both encoding and consolidation of memories within hippocampal circuits.SIGNIFICANCE STATEMENT Memory ensembles in the hippocampus are formed during active exploration ...Continue Reading

Citations

Aug 30, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Jiandong SunXiaoning Bi
Mar 3, 2020·Neuroscience·D Fernández-Fernández, J A Lamas
Aug 24, 2020·Neuroscience·Marco FuenzalidaAndrés E Chávez
Mar 2, 2021·Behavioural Brain Research·Daniel J FosterP Jeffrey Conn
Sep 21, 2019·Neurobiology of Learning and Memory·Dominique Debanne, Michaël Russier
Aug 8, 2021·Neuropharmacology·Jeffrey C WatkinsBruno G Frenguelli

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