Convergent neuromodulation onto a network neuron can have divergent effects at the network level

Journal of Computational Neuroscience
Nickolas KintosF Nadim

Abstract

Different neuromodulators often target the same ion channel. When such modulators act on different neuron types, this convergent action can enable a rhythmic network to produce distinct outputs. Less clear are the functional consequences when two neuromodulators influence the same ion channel in the same neuron. We examine the consequences of this seeming redundancy using a mathematical model of the crab gastric mill (chewing) network. This network is activated in vitro by the projection neuron MCN1, which elicits a half-center bursting oscillation between the reciprocally-inhibitory neurons LG and Int1. We focus on two neuropeptides which modulate this network, including a MCN1 neurotransmitter and the hormone crustacean cardioactive peptide (CCAP). Both activate the same voltage-gated current (I MI ) in the LG neuron. However, I MI-MCN1 , resulting from MCN1 released neuropeptide, has phasic dynamics in its maximal conductance due to LG presynaptic inhibition of MCN1, while I MI-CCAP retains the same maximal conductance in both phases of the gastric mill rhythm. Separation of time scales allows us to produce a 2D model from which phase plane analysis shows that, as in the biological system, I MI-MCN1 and I MI-CCAP primarily i...Continue Reading

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Jul 28, 2016·Current Opinion in Neurobiology·Nelly DaurDirk Bucher
Oct 4, 2016·Current Opinion in Neurobiology·Patsy S DickinsonMeredith E Stanhope
Feb 14, 2018·The Journal of Experimental Biology·Kellen DeLaneyLingjun Li
Nov 23, 2018·The Journal of Experimental Biology·Patsy S DickinsonAndrew E Christie

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