Convergent synthesis of the pentasaccharide repeating unit of the O-antigenic polysaccharide of enterohaemorrhagic Escherichia coli O113.

Glycoconjugate Journal
Abhishek Santra, Anup Kumar Misra

Abstract

An acidic pentasaccharide repeating unit corresponding to the O-antigenic polysaccharide of enterohaemorrhagic Escherichia coli O113 as its p-methoxyphenyl glycoside has been synthesized in a convergent manner by adopting a [3+2] block glycosylation strategy. During the synthetic endeavor a one-pot reaction condition for stereoselective glycosylation and protecting group manipulation has been applied. All glycosylation steps are highly stereoselective with good to excellent yield.

References

Aug 10, 1995·The New England Journal of Medicine·T G BoyceP M Griffin
Mar 6, 1999·Current Opinion in Microbiology·J B Kaper
Oct 26, 1999·The Pediatric Infectious Disease Journal·J R Bower
Jul 29, 2000·Bioorganic & Medicinal Chemistry Letters·A K MisraO Hindsgaul
Apr 28, 2005·Carbohydrate Research·Geetanjali AgnihotriAnup Kumar Misra
Oct 22, 2005·International Journal of Medical Microbiology : IJMM·Helge KarchMartina Bielaszewska
Apr 6, 2006·FEMS Microbiology Reviews·Roland StenutzGöran Widmalm
Dec 1, 2004·Drug Discovery Today. Technologies·René Roy

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiac Glycosides

Cardiac glycosides are a diverse family of naturally derived compounds that bind to and inhibit na+/k+-atpase. Discover the latest research on cardiac glycosides heres.