Converging cellular themes for the hereditary spastic paraplegias

Current Opinion in Neurobiology
Craig Blackstone

Abstract

Hereditary spastic paraplegias (HSPs) are neurologic disorders characterized by prominent lower-extremity spasticity, resulting from a length-dependent axonopathy of corticospinal upper motor neurons. They are among the most genetically-diverse neurologic disorders, with >80 distinct genetic loci and over 60 identified genes. Studies investigating the molecular pathogenesis underlying HSPs have emphasized the importance of converging cellular pathogenic themes in the most common forms of HSP, providing compelling targets for therapy. Most notably, these include organelle shaping and biogenesis as well as membrane and cargo trafficking.

References

Aug 9, 2006·Human Molecular Genetics·Jonathan D WoodVincent T Cunliffe
Mar 25, 2009·The Journal of Cell Biology·Scott W EastmanPaul D Bieniasz
Apr 23, 2013·Biochimica Et Biophysica Acta·Uma Goyal, Craig Blackstone
May 21, 2013·Cell Reports·Robin W KlemmHo Yi Mak
Aug 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jaerak ChangCraig Blackstone
Jan 2, 2014·Human Molecular Genetics·Steven HavlicekBeate Winner
Nov 5, 2014·The Journal of Clinical Investigation·Jaerak ChangCraig Blackstone
Apr 16, 2015·PLoS Genetics·Chrisovalantis PapadopoulosElena I Rugarli
Jul 24, 2015·Annals of Neurology·Youngshin LimJeffrey A Golden
Dec 3, 2015·Nature Reviews. Molecular Cell Biology·Melissa J Phillips, Gia K Voeltz
Feb 26, 2016·Journal of Cell Science·James B SummervilleJames A McNew
Jul 13, 2016·The Journal of Biological Chemistry·Pradeep Kumar Yadav, Ram Rajasekharan
Nov 2, 2016·Molecular Biology of the Cell·Kavitha RaoMelissa M Rolls
Sep 9, 2016·Neurology. Genetics·Jennifer HirstMichael C Kruer
Oct 30, 2016·Science·Jonathon Nixon-AbellJennifer Lippincott-Schwartz
Nov 24, 2016·The EMBO Journal·Veijo T SaloElina Ikonen
Dec 3, 2016·Journal of Cell Science·Shiyu XuJames A McNew
Apr 9, 2017·The Journal of Cell Biology·Rachel AllisonEvan Reid
Jun 1, 2017·Proceedings of the National Academy of Sciences of the United States of America·Yumei WuPietro De Camilli
Jun 25, 2017·Journal of Cell Science·Olga AlekhinaDaniel D Billadeau
Aug 11, 2017·Annual Review of Cell and Developmental Biology·Tobias C WaltherRobert V Farese
Nov 11, 2017·Brain : a Journal of Neurology·Ludger SchölsRebecca Schüle
Nov 15, 2017·Developmental Neurobiology·Alejandro LuarteAndrés Couve
Nov 29, 2017·Proceedings of the National Academy of Sciences of the United States of America·Rafael MatteraJuan S Bonifacino
Dec 12, 2017·Brain : a Journal of Neurology·Cecilia MarelliFanny Mochel
Jan 24, 2018·Journal of Cell Science·Mark Terasaki
Jan 31, 2018·PLoS Biology·Jennifer HirstMargaret S Robinson
Feb 27, 2018·Handbook of Clinical Neurology·Craig Blackstone

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Citations

Jul 7, 2019·The Journal of Cell Biology·W Mike Henne
Apr 30, 2020·Molecular & Cellular Proteomics : MCP·Georg H H Borner
Dec 12, 2018·Frontiers in Neurology·Dana M Bis-Brewer, Stephan Züchner
Jun 23, 2019·The Journal of Cell Biology·Chi-Lun ChangJennifer Lippincott-Schwartz
Aug 10, 2019·International Journal of Molecular Sciences·Baris GencP Hande Ozdinler
Mar 3, 2020·Frontiers in Neuroscience·Zeynep ÖztürkJuan José Pérez-Moreno
Jul 28, 2020·Frontiers in Cell and Developmental Biology·Chao ChenWei Wang
Dec 14, 2018·Nature Reviews. Molecular Cell Biology·James A Olzmann, Pedro Carvalho
Oct 17, 2019·Frontiers in Cellular Neuroscience·Dominik R GabrychMichael A Silverman
May 8, 2020·Cell Discovery·Eleanna StamatakouDavid Chaim Rubinsztein
Aug 15, 2020·Frontiers in Cell and Developmental Biology·Mohammad F ZamanChristopher T Beh
Apr 24, 2020·Life Science Alliance·Nimesha TadepalleElena I Rugarli
Oct 20, 2020·Frontiers in Cell and Developmental Biology·Stefan HauserLudger Schöls
Oct 27, 2020·Brain : a Journal of Neurology·Thomas T Warner
Nov 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Florian GeltingerMark Rinnerthaler
Jan 28, 2021·Brain Sciences·Daisy EdmisonSwetha Gowrishankar
Feb 13, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Katiane R ServelhereMarcondes C França
Jan 17, 2021·Molecular & Cellular Proteomics : MCP·Georg H H Borner
Feb 28, 2021·Journal of the Formosan Medical Association = Taiwan Yi Zhi·Shao-Lun HsuYi-Chung Lee
May 6, 2021·Cell Discovery·Eleanna StamatakouDavid Chaim Rubinsztein
May 28, 2021·Frontiers in Molecular Biosciences·Nimesha Tadepalle, Elena I Rugarli
Jun 1, 2021·Frontiers in Pharmacology·Mercedes Garcia-GilMaria Grazia Tozzi
Jun 30, 2021·Molecular Genetics and Metabolism·Darius Ebrahimi-FakhariPhillip L Pearl
Aug 18, 2021·Current Opinion in Neurobiology·Frédéric DariosAlexandra Durr
Sep 7, 2021·Journal of Neurology·Stefania Della VecchiaFilippo Maria Santorelli
Oct 13, 2021·Movement Disorders : Official Journal of the Movement Disorder Society·Derek E NeilsonTaosheng Huang
Sep 27, 2021·Annals of Neurology·Claudia SchobJonas Denecke
Dec 17, 2021·Nature·Pengli ZhengCraig Blackstone
Dec 14, 2021·Frontiers in Molecular Biosciences·Liena E O ElsayedGiovanni Stevanin

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