Conversations with Ray Guillery on albinism: linking Siamese cat visual pathway connectivity to mouse retinal development

The European Journal of Neuroscience
Carol A Mason, R W Guillery

Abstract

In albinism of all species, perturbed melanin biosynthesis in the eye leads to foveal hypoplasia, retinal ganglion cell misrouting, and, consequently, altered binocular vision. Here, written before he died, Ray Guillery chronicles his discovery of the aberrant circuitry from eye to brain in the Siamese cat. Ray's characterization of visual pathway anomalies in this temperature sensitive mutation of tyrosinase and thus melanin synthesis in domestic cats opened the exploration of albinism and simultaneously, a genetic approach to the organization of neural circuitry. I follow this account with a remembrance of Ray's influence on my work. Beginning with my postdoc research with Ray on the cat visual pathway, through my own work on the mechanisms of retinal axon guidance in the developing mouse, Ray and I had a continuous and rich dialogue about the albino visual pathway. I will present the questions Ray posed and clues we have to date on the still-elusive link between eye pigment and the proper balance of ipsilateral and contralateral retinal ganglion cell projections to the brain.

References

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Citations

Apr 7, 2019·The European Journal of Neuroscience·J Paul Bolam, John J Foxe
Apr 11, 2019·The European Journal of Neuroscience·Carol A Mason, S Murray Sherman
May 13, 2020·Annual Review of Vision Science·Carol Mason, Nefeli Slavi
Oct 27, 2020·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Perrine PennamenBenoit Arveiler

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