PMID: 16614538Apr 15, 2006Paper

Conversion from sustained release carbidopa/levodopa to carbidopa/levodopa/entacapone (stalevo) in Parkinson disease patients

Clinical Neuropharmacology
Kelly E Lyons, Rajesh Pahwa

Abstract

This study was performed to determine if conversion from sustained release carbidopa/levodopa (SR-CL) with or without entacapone to carbidopa/levodopa/entacapone (CLE; Stalevo) improves motor functioning and quality of life in Parkinson disease (PD) patients and to assess patient tolerance and drug preference. PD patients reporting suboptimal symptom control with SR-CL were converted to CLE. The basic conversion was 1 SR-CL 25/100 to 1 25/100/200 CLE and 1 SR-CL 50/200 to 1 37.5/150/200 CLE with additional changes as necessary. There were 62 patients with an average age of 68 years and an average disease duration of 11 years. CLE was preferred by 42 patients and SR-CL was preferred by 20 patients. In those that preferred CLE, Unified Parkinson Disease Rating Scale (UPDRS) mentation and motor subscores, Parkinson Disease Questionnaire-39 (PDQ-39) quality-of-life activities of daily living (ADL) and bodily discomfort subscores, and Epworth Sleepiness Scale (ESS) scores were significantly improved. There were no significant changes in any measures in the group that preferred SR-CL. Common adverse effects in the group that preferred CLE included nausea, vomiting, increased dyskinesia or off time, dizziness, and somnolence. The most...Continue Reading

Citations

Sep 1, 2006·Photomedicine and Laser Surgery
Mar 9, 2007·Movement Disorders : Official Journal of the Movement Disorder Society·Pablo Martinez-Martin, Günther Deuschl
May 5, 2010·CNS Neuroscience & Therapeutics·Zsigmond Tamas Kincses, Laszlo Vecsei
Feb 22, 2011·Expert Opinion on Drug Metabolism & Toxicology·Nikoletta SzabóLászló Vécsei
Jun 9, 2018·The International Journal of Neuroscience·Asmat Ullah KhanRida Zainab
Aug 8, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Stephen D Aradi, Robert A Hauser

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