PMID: 6165806May 1, 1981Paper

Conversion of 3, 4-dihydroxyphenylalanine and deuterated 3, 4-dihydroxyphenylalanine to alcoholic metabolites of catecholamines in rat brain

Journal of Neurochemistry
D J Edwards, M Rizk

Abstract

We have investigated the effects of 3, 4-dihydroxyphenylalanine (L-DOPA) and its deuterated analogue on the concentrations of alcoholic metabolites of catecholamines in rat brain by means of gas chromatography/mass spectrometry with selected-ion monitoring. Whole brain concentrations of the two neutral norepinephrine metabolites, 3-methoxy-4-hydroxyphenylethyleneglycol (MHPG) and 3, 4-dihydroxyphenylethyleneglycol (DHPG), were significantly increased in a dose-dependent manner by a single intraperitoneal injection of L-DOPA. Both MHPG and DHPG, as well as the corresponding dopamine metabolites, reached a maximum 1 h after injection. Brain MHPG and DHPG concentrations were elevated by 78 and 134%, respectively, 1 h after injection of 150 mg/kg L-DOPA. Analyses of discrete brain regions revealed that concentrations of the norepinephrine metabolites were elevated uniformly in all regions, except that MHPG showed a greater increase in the cerebellum than in other regions. The latter result appeared to be explained by the finding that 52% of the total MHPG in the cerebellum was unconjugated (compared to 15% in the whole brain). L-DOPA caused a proportionately greater increase in free MHPG than in total MHPG in the cerebellum and bra...Continue Reading

References

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Citations

Aug 1, 1985·Biological Psychiatry·M L Sedlock, D J Edwards
Jan 1, 1981·Progress in Neuro-psychopharmacology·D J Edwards, M Rizk
Aug 9, 2003·Neuropharmacology·Lior Dayan, John P M Finberg
May 1, 1997·Pharmacology, Biochemistry, and Behavior·E T Hellriegel, A P D'Mello
Apr 27, 2010·Nutrition Reviews·Sergio Granados-PrincipalM Carmen Ramirez-Tortosa
Nov 26, 2015·Neuroscience and Biobehavioral Reviews·Marta MiquelGenaro A Coria-Avila
Jun 1, 1984·Journal of Neurochemistry·J W Commissiong
Apr 1, 1985·Journal of Neurochemistry·J W Commissiong
Apr 1, 1988·The Journal of Pharmacy and Pharmacology·C J Gibson
Jan 1, 1989·Movement Disorders : Official Journal of the Movement Disorder Society·E MohrT N Chase
Oct 1, 1982·The Journal of Pharmacy and Pharmacology·D J Edwards, M L Sedlock
Jun 1, 1989·Biochemical Pharmacology·N T Buu

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