Conversion of angiotensin I to angiotensin II in dog isolated renal artery: role of two different angiotensin II-generating enzymes

Journal of Cardiovascular Pharmacology
T OkamuraN Toda


The functional role of the endothelium in conversion of angiotensin (Ang) I to Ang II was studied in helical strips of dog renal arteries. In the arteries precontracted with PGF2 alpha, Angs I and II caused a moderate relaxation, which was abolished by treatment with saralasin and reversed to a contraction by indomethacin. Removal of the endothelium attenuated the response to Ang I but did not abolish it. The Ang I-induced relaxation in the arteries without endothelium was not significantly attenuated by an Ang-converting enzyme inhibitor, SA446, but was markedly suppressed by chymostatin. On the other hand, in the arteries with endothelium, the relaxation was suppressed but not abolished by SA446, and the remaining relaxation was abolished by additional treatment with chymostatin. Relaxation induced by prostaglandin I2 was unaffected by these enzyme inhibitors. These results strongly suggest that the conversion of Ang I to Ang II is due mainly to the Ang-converting enzyme in the endothelium and to the chymostatin-sensitive Ang II-generating enzyme in subendothelial tissues.


Jan 24, 1998·Biochemical and Biophysical Research Communications·D YamamotoM Miyazaki
Jun 24, 1992·European Journal of Pharmacology·M H Nelissen-VranckenJ F Smits
May 30, 1996·The American Journal of Cardiology·I S Blaufarb, E H Sonnenblick
Oct 1, 1992·Experimental Eye Research·T OkamuraN Toda
Apr 6, 2000·Current Opinion in Lipidology·R De Caterina
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Dec 1, 1992·British Journal of Pharmacology·T OkamuraN Toda
Mar 20, 2001·The Journal of Clinical Investigation·C GuoM Rabinovitch
Mar 1, 1997·Clinical and Experimental Pharmacology & Physiology·N ShiotaM Miyazaki
Nov 1, 1993·Hypertension·H J Nelissen-VranckenJ F Smits
Apr 1, 1997·Journal of Hypertension·N ShiotaM Miyazaki
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Nov 21, 2000·Current Opinion in Clinical Nutrition and Metabolic Care·R De Caterina
Jan 22, 1998·The American Journal of Physiology·E A GarrisonP J Kadowitz

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