PMID: 2492827Feb 20, 1989Paper

Conversion of apolipoprotein-specific high-density lipoprotein populations during incubation of human plasma

Biochimica Et Biophysica Acta
A V NicholsE L Gong

Abstract

Incubation studies were performed on plasma obtained from subjects selected for relatively low levels of high-density lipoprotein cholesterol (HDL-C) (no greater than 30 mg/dl) and particle size distributions enriched in the HDL3 subclass. Incubation (12 h, 37 degrees C) of plasma in the presence or absence of lecithin: cholesterol acyltransferase activity produces marked alteration in size profiles of both major apolipoprotein-specific HDL3 populations (HDL3(AI w AII), HDL3 species containing both apolipoprotein A-I and apolipoprotein A-II, and HDL3(AI w/o AII), HDL3 species containing apolipoprotein A-I) as isolated by immunoaffinity chromatography. In the presence or absence of lecithin: cholesterol acyltransferase activity, plasma incubation results in a shift of HDL3(AI w AII) species (initial mean sizes of major components, approx. 8.8 and 8.0 nm) predominantly to larger particles (mean size, 9.8 nm). A less prominent shift to smaller particles (mean size, 7.8 nm) accompanies the conversion to larger particles only when the enzyme is active. Combined shifts to larger (mean size, 9.8 nm) and smaller (mean size, 7.4 nm) particles are observed for HDL3(AI w/o AII) particles (mean size, 8.3 nm) also only in the presence of en...Continue Reading

References

Mar 1, 1986·Clinical Science·D Reichl, N E Miller
Jul 1, 1987·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·G FranceschiniA V Nichols
May 2, 1988·Biochimica Et Biophysica Acta·M C CheungC R Sirtori
Apr 24, 1987·Biochimica Et Biophysica Acta·J L EllsworthJ A Harmony
Oct 14, 1982·Biochimica Et Biophysica Acta·P GambertP Padieu
May 15, 1981·Biochemical and Biophysical Research Communications·A V NicholsP J Blanche
Aug 2, 2005·Molecular and Cellular Biology·Nir E RubinsKlaus H Kaestner

❮ Previous
Next ❯

Citations

May 1, 1995·The International Journal of Biochemistry & Cell Biology·M KongshaugA R Morgan
Jan 15, 2013·Journal of Clinical Lipidology·H Robert SuperkoBrenda C Garrett
Nov 18, 2006·Clinics in Laboratory Medicine·G Russell WarnickCleland C Landolt
Nov 1, 1994·Metabolism: Clinical and Experimental·P T WilliamsR M Krauss
Jun 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·D L RainwaterJ L VandeBerg
Mar 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·P T WilliamsF T Lindgren
Dec 1, 1992·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·P T WilliamsR M Krauss
Nov 1, 1993·Arteriosclerosis and Thrombosis : a Journal of Vascular Biology·P T WilliamsR M Krauss
Sep 1, 1995·Arteriosclerosis, Thrombosis, and Vascular Biology·J CoreshP O Kwiterovich
Apr 1, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·P T WilliamsR M Krauss
Nov 11, 1996·Biochimica Et Biophysica Acta·L CalabresiG Franceschini
Jan 25, 1995·Biochimica Et Biophysica Acta·S I SkarlatosH S Kruth
Mar 4, 1992·Biochimica Et Biophysica Acta·L CalabresiG Franceschini
Oct 1, 1991·Biochimica Et Biophysica Acta·A V NicholsE L Gong

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.