PMID: 8609325Apr 1, 1996Paper

Conversion of atrial flutter by ibutilide is associated with increased atrial cycle length variability

Journal of the American College of Cardiology
G B GuoB S Stambler

Abstract

This study was designed to test the hypothesis that conversion of atrial flutter in humans by ibutilide, a new class III antiarrhythmic agent, is characterized by an increase in atrial cycle length variability. Conversion of tachyarrhythmias has been associated with increased oscillations of cycle length. Electrograms and monophasic action potentials from the right atrium in 35 patients with spontaneous, sustained atrial flutter were recorded before, during and after intravenous ibutilide (0.005 to 0.025 mg/kg body weight, n = 25) or placebo (n = 10). Atrial cycle length, cycle length variability (coefficient of variation), diastolic interval and diastolic interval variability were measured from 10 consecutive cycles at baseline and 3 min before, 1 min before, 30 s before and immediately before conversion. Similar measurements were made in patients who received ibutilide or placebo but did not convert. Ibutilide converted atrial flutter in 14 of 25 patients 25 +/- 16 min (mean +/- SD) after initiation of the infusion, whereas placebo converted no patients. Atrial cycle length was prolonged to the same extent in ibutilide converters and nonconverters (36 +/- 19 vs. 38 +/- 21 ms, p = NS) and was not affected by placebo. Beat-to-b...Continue Reading

References

Dec 1, 1992·Pacing and Clinical Electrophysiology : PACE·B OlshanskyR J Hariman
Apr 1, 1991·Journal of the American College of Cardiology·H J Wellens

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Citations

Jun 2, 2000·Pacing and Clinical Electrophysiology : PACE·R A Schwartz, J J Langberg
Nov 30, 2007·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Ian G StiellGeorge A Wells
May 10, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Hidehiko NagasawaHiroshi Inoue
Aug 8, 2008·Pacing and Clinical Electrophysiology : PACE·Norishige MoritaKyoichi Mizuno
Apr 24, 2013·Pacing and Clinical Electrophysiology : PACE·Hiroshige YamabeHisao Ogawa
Oct 17, 1996·The American Journal of Cardiology·K A EllenbogenJ T VanderLugt
Sep 8, 2009·Pacing and Clinical Electrophysiology : PACE·Peter E Zambito, Eugen C Palma
Jun 2, 2005·Expert Opinion on Investigational Drugs·Sheila A Doggrell, Jules C Hancox
May 29, 1999·American Heart Journal·K A EllenbogenB S Stambler
Apr 20, 2005·Journal of the American College of Cardiology·Sanjiv M NarayanValmik Bhargava
Mar 7, 1998·Circulation·K T Murray

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