Conversion of brain apolipoprotein E to an insoluble form in a mouse model of Alzheimer disease

Neuroreport
A NaiduB Cordell

Abstract

A beta deposition in the APPV717F transgenic model of Alzheimer's pathology involves apolipoprotein E (apoE). We measured soluble and insoluble apoE in brain region extracts at an early and late stage of plaque development. The apoE levels in the insoluble fraction were greatly elevated in the hippocampus and cortex of aged transgenic animals but were unchanged in wild type or young APPV717F animals. Soluble apoE levels were unaltered. A beta levels were also measured and a positive correlation between apoE and A beta in the insoluble fraction was observed. ApoE transcription was increased approximately 3-fold in the hippocampus of 17-month-old APPV717F mice, suggesting a region-specific upregulation of apoE transcription in the brains of APPV717F mice to compensate for apoE sequestered with fibrillar A beta.

References

Nov 9, 1995·The New England Journal of Medicine·T PolvikoskiK Kontula
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·G D Schellenberg
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·W J Strittmatter, A D Roses
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D E SchmechelA D Roses
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J StrittmatterA D Roses
Mar 1, 1996·Annals of Neurology·M GearingS S Mirra
Feb 18, 1997·Proceedings of the National Academy of Sciences of the United States of America·K Johnson-WoodL McConlogue
Dec 16, 1997·Proceedings of the National Academy of Sciences of the United States of America·C Sturchler-PierratB Sommer
Dec 17, 1997·Biochemical and Biophysical Research Communications·B PermanneT Wisniewski
Aug 26, 1998·Brain : a Journal of Neurology·S Hawke
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·C RussoM Tabaton
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·K R BalesS M Paul

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.