Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture

Nature Biotechnology
Qi-Long YingAustin Smith

Abstract

Mouse embryonic stem (ES) cells are competent for production of all fetal and adult cell types. However, the utility of ES cells as a developmental model or as a source of defined cell populations for pharmaceutical screening or transplantation is compromised because their differentiation in vitro is poorly controlled. Specification of primary lineages is not understood and consequently differentiation protocols are empirical, yielding variable and heterogeneous outcomes. Here we report that neither multicellular aggregation nor coculture is necessary for ES cells to commit efficiently to a neural fate. In adherent monoculture, elimination of inductive signals for alternative fates is sufficient for ES cells to develop into neural precursors. This process is not a simple default pathway, however, but requires autocrine fibroblast growth factor (FGF). Using flow cytometry quantitation and recording of individual colonies, we establish that the bulk of ES cells undergo neural conversion. The neural precursors can be purified to homogeneity by fluorescence activated cell sorting (FACS) or drug selection. This system provides a platform for defining the molecular machinery of neural commitment and optimizing the efficiency of neuro...Continue Reading

References

Apr 1, 1995·Developmental Biology·G BainD I Gottlieb
Jan 13, 1995·Science·B FeldmanM Goldfarb
Dec 1, 1995·Current Opinion in Cell Biology·Gordon Keller
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·E ArmanP Lonai
Feb 27, 1999·Experimental Cell Research·M V Wiles, B M Johansson
Jan 3, 2001·Nature Neuroscience·K L TuckerY A Barde
Nov 1, 2001·Annual Review of Cell and Developmental Biology·A Smith
Nov 1, 2001·Nature Neuroscience·S I Wilson, T Edlund
Apr 5, 2002·Nature·Qi-Long YingAustin Smith
Apr 23, 2002·Nature Reviews. Neuroscience·Ignacio Muñoz-Sanjuán, Ali H Brivanlou

Citations

Jan 6, 2010·EMBO Molecular Medicine·Austin Smith
Jul 26, 2011·Cellular and Molecular Life Sciences : CMLS·Huisheng Liu, Su-Chun Zhang
May 25, 2011·Journal of Neural Transmission·Zhi-qiang WangJean C Shih
Oct 29, 2005·Bulletin of Experimental Biology and Medicine·O V PodgornyiM A Aleksandrova
Mar 23, 2011·Cellular and Molecular Neurobiology·Ying JingStefan Krauss
Feb 22, 2011·Neurochemical Research·Jun Aruga, Katsuhiko Mikoshiba
Dec 5, 2006·Stem Cell Reviews·Natalia AleninaMichael Bader
Dec 5, 2006·Stem Cell Reviews·Patricia G Wilson, Steve S Stice
Jul 13, 2007·Stem Cell Reviews·M William LenschThorsten M Schlaeger
Jan 22, 2004·Archives of Medical Research·José-Manuel BaizabalLuis Covarrubias
Nov 9, 2005·Blood Reviews·Paul H Lerou, George Q Daley
Oct 1, 2013·Genomics, Proteomics & Bioinformatics·Guangjun XiQi-Long Ying
Apr 1, 2009·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Xu MaisanoJanice R Naegele
Sep 21, 2013·Stem Cell Reports·Harry G LeitchAustin Smith
Jun 16, 2005·Trends in Neurosciences·Tamara Glaser, Oliver Brüstle
Nov 19, 2003·Developmental Biology·David A F LoebelPatrick P L Tam
Dec 11, 2003·Molecular and Cellular Neurosciences·Lorenz HaegeleSebastian Brandner
Jan 6, 2010·Journal of Medicinal Chemistry·Agnès I LukaszewiczMichael Kahn
Jul 16, 2011·Molecular Pharmaceutics·Esther Xingwei LeeS Wang
Jul 28, 2013·Cell Death & Disease·Yasmine HadjalBernard Binétruy
Dec 31, 2008·Cell Research·Tetsuro Watabe, Kohei Miyazono
Dec 22, 2007·Nature·Ian ChambersAustin Smith
Aug 30, 2011·Nature·Mitchell GuttmanEric S Lander
Jun 26, 2012·Nature Biotechnology·Ethan S LippmannEric V Shusta
Feb 3, 2005·Nature Biotechnology·Xue-Jun LiSu-Chun Zhang
Sep 21, 2010·Nature Cell Biology·Jolly MazumdarM Celeste Simon
May 4, 2010·Nature Chemical Biology·Oscar YanesGary Siuzdak
Jun 6, 2009·Nature Medicine·Jennifer NicholsAnne Cooke
Nov 9, 2010·Nature Methods·Jason G UnderwoodDavid Haussler
Feb 14, 2012·Nature Methods·Debojyoti ChakrabortyFrank Buchholz
Apr 22, 2006·Nature Methods·Christoph SchanielPatrick J Paddison
Mar 23, 2005·Nature Methods·Christopher J FlaimSangeeta N Bhatia
Feb 8, 2005·Nature Neuroscience·Kiichi WatanabeYoshiki Sasai
Apr 5, 2007·Nature Protocols·Insa S SchroederAnna M Wobus
Oct 3, 2009·Nature Protocols·Nicolas GaspardPierre Vanderhaeghen
May 16, 2009·Nature Protocols·Fumitaka OsakadaMasayo Takahashi
Aug 2, 2007·Nature Reviews. Drug Discovery·Colin W Pouton, John M Haynes
Dec 15, 2007·Nature Reviews. Drug Discovery·Irina KlimanskayaRobert Lanza
May 25, 2007·Nature Reviews. Molecular Cell Biology·Shin-Ichi NishikawaTakumi Era
Feb 19, 2013·Nature Structural & Molecular Biology·Harry G LeitchPetra Hajkova
Nov 29, 2005·Cell Death and Differentiation·Karen GambaroMatthieu Rouleau
Oct 4, 2006·Gene Therapy·F Yates, George Q Daley
Sep 27, 2007·Molecular Therapy : the Journal of the American Society of Gene Therapy·David AndersonChris Denning
Dec 7, 2006·Reproduction, Fertility, and Development·Steven L SticeSoojung Shin
Sep 7, 2012·Reproduction, Fertility, and Development·Maryam PashaiaslPaul J Verma
Aug 14, 2008·Proceedings of the National Academy of Sciences of the United States of America·Takafumi WatayaYoshiki Sasai
Apr 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Stina FrilingJohan Ericson
Nov 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·Tomoki YokochiDavid M Gilbert
Mar 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jia Qian WuMichael Snyder
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Rohit SachdevaJohan Jakobsson
Feb 9, 2011·Proceedings of the National Academy of Sciences of the United States of America·Dhananjay YellajoshyulaKristen L Kroll
May 18, 2011·Proceedings of the National Academy of Sciences of the United States of America·Nicole GennetMeng Li
Apr 28, 2011·Proceedings of the National Academy of Sciences of the United States of America·Janghwan KimSheng Ding
Jul 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Shin-Ichiro TakebayashiDavid M Gilbert
Apr 12, 2013·Proceedings of the National Academy of Sciences of the United States of America·Seth MalmersjöPer Uhlén
Aug 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Jerome AubertAustin Smith
Dec 22, 2009·The Journal of Biological Chemistry·Daniel C KraushaarLianchun Wang
Jun 28, 2011·The Journal of Biological Chemistry·Bhanu Prakash V L TeluguR Michael Roberts
Feb 3, 2012·The Journal of Biological Chemistry·M ForsbergKarin Forsberg-Nilsson
Dec 14, 2012·The Journal of Biological Chemistry·Kate A MeadeCatherine L R Merry
Feb 24, 2004·Journal of Hematotherapy & Stem Cell Research·Su-Chun Zhang
Feb 6, 2010·Cellular Reprogramming·Yu-Qiang Li
Oct 13, 2010·Cellular Reprogramming·Maryam PashaiaslPaul J Verma
Mar 5, 2008·Cloning and Stem Cells·Norshariza NordinJohn O Mason
Sep 3, 2005·Stem Cells and Development·Reza IzadpanahBruce A Bunnell
Jul 6, 2007·Stem Cells and Development·Theresa L ChenFredric B Kraemer
May 2, 2006·Stem Cells and Development·Deanne TibbittsSteven L Stice
Apr 30, 2009·Stem Cells and Development·Leonie du PuyBernard A J Roelen
Feb 6, 2010·Stem Cells and Development·Dorota SadowskiRandall D McKinnon
Jan 20, 2011·Stem Cells and Development·Olympia E PsathakiHans R Schöler
May 19, 2012·Stem Cells and Development·Lan DangVincent Tropepe
Sep 7, 2013·Stem Cells and Development·Ulrika MarklundJohan Ericson
Apr 28, 2006·Molecular Biology of the Cell·Chen WangNaihe Jing
Apr 13, 2007·Molecular Biology of the Cell·Sandra LubitzKonstantinos Anastassiadis
Jan 30, 2009·Molecular Biology of the Cell·Lachlan A JollyStephen A Wood
Dec 25, 2009·Brain : a Journal of Neurology·Stefania CortiGiacomo P Comi
Mar 9, 2010·Brain : a Journal of Neurology·A J TrevelyanDoug M Turnbull
Dec 30, 2008·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Kazuhiro AibaMinoru S H Ko
Jul 18, 2008·Human Molecular Genetics·Julie Gaulden, Jeremy F Reiter
Mar 2, 2012·Nucleic Acids Research·Leonid Schneider, Fabrizio d'Adda di Fagagna
Apr 12, 2012·Nucleic Acids Research·Konstantinia SkrekaAlexander Hüttenhofer
Aug 27, 2004·Biology of Reproduction·K Sue O'Shea
Feb 22, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Nicholas D Allen
Feb 27, 2007·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Su-Chun ZhangMatthew T Pankratz
Jul 6, 2011·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Jem A Efe, Sheng Ding
Oct 1, 2010·Clinical and Experimental Pharmacology & Physiology·Chen-Xia HeUte Christine Rogner
Aug 20, 2005·Development, Growth & Differentiation·Shoen Kume
Mar 13, 2012·Development, Growth & Differentiation·Keiko Muguruma, Yoshiki Sasai
Jul 30, 2008·Molecular and Cellular Biology·Debbie L C van den BergRaymond A Poot
Jun 27, 2007·Molecular and Cellular Biology·Mikaël AttiaUte Christine Rogner
Jul 30, 2008·Molecular and Cellular Biology·Anke Hoffmann, Dietmar Spengler
Nov 30, 2005·Molecular and Cellular Biology·Claudia R AmuraLynn Heasley
Dec 16, 2005·Molecular and Cellular Biology·Anna ProkhortchoukAdrian Bird
Jan 12, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Elke Muth-KöhneMichael Hollmann
Mar 26, 2013·The Journal of Clinical Investigation·Lu CuiYing Jin
Nov 21, 2007·Hematology·Mickie Bhatia
May 1, 2010·Journal of Biomedical Science·Ching-Wen ChenHong-Lin Su
Jul 21, 2007·BMC Developmental Biology·Malin Parmar, Meng Li
Jan 13, 2009·BMC Developmental Biology·Fiona C ManserghMartin J Evans
Sep 28, 2010·BMC Genomics·Márcia M AranhaCecília M P Rodrigues
Oct 24, 2003·BMC Neuroscience·Thomas C SchulzBrian G Condie
Jun 28, 2012·BMC Gastroenterology·Valentina SasselliPankaj Jay Pasricha
Jun 18, 2004·Reproductive Biology and Endocrinology : RB&E·K-Y Francis Pau, Don P Wolf
Dec 1, 2007·Genome Biology·Darren J SchofieldJohn McCafferty
Nov 22, 2012·Stem Cell Research & Therapy·Krista M FridleyTodd C McDevitt
Mar 22, 2006·Pediatric Research·Hao Wu, Yi Eve Sun
May 11, 2005·PLoS Biology·Antigoni EkonomouVasso Episkopou
Aug 10, 2005·PLoS Biology·Luciano ContiAustin Smith
Apr 6, 2006·PLoS Biology·Sally LowellAustin Smith
Oct 10, 2008·PLoS Biology·Ichiro HirataniDavid M Gilbert
Mar 16, 2007·PloS One·Tamara GlaserOliver Brüstle
Dec 20, 2007·PloS One·Nibedita Lenka, Saravana Kumar Ramasamy
Jun 10, 2010·PloS One·Peter D TongePeter Andrews
Nov 26, 2010·PloS One·Maria KeramariSusan J Kimber
Jul 27, 2011·PloS One·Sanae HamanakaHiromitsu Nakauchi
Aug 11, 2011·PloS One·Katarina BlagovićJoel Voldman
Sep 3, 2011·PloS One·Jessica R Risner-JaniczekMeng Li
Sep 1, 2012·PloS One·Courtney S OnoderaDavid Haussler
Apr 23, 2014·PloS One·Nicholas RogersPaul Q Thomas
Mar 23, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·M Austin JohnsonSu-Chun Zhang
Mar 1, 2013·Epilepsy Currents·Robert F Hunt, Scott C Baraban
Mar 19, 2014·Biomaterials·Angela BozzaSimona Casarosa
May 27, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Fariborz IzadyarFrancisco Silva
May 1, 2007·Regenerative Medicine·Sebnem Daniels
May 1, 2007·Regenerative Medicine·Lan Dang, Vincent Tropepe
Mar 13, 2013·Regenerative Medicine·Paul Mondragon-TeranFarlan S Veraitch
May 1, 2007·Regenerative Medicine·Steven M PollardAustin Smith
Jun 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Morio UenoYoshiki Sasai
Apr 25, 2006·Proceedings of the National Academy of Sciences of the United States of America·Shuyuan YaoSheng Ding
Sep 25, 2003·Proceedings of the National Academy of Sciences of the United States of America·Kent E VranaJose B Cibelli
Apr 6, 2006·Proceedings of the National Academy of Sciences of the United States of America·Takeo KatoTatsutoshi Nakahata
Jun 15, 2006·Proceedings of the National Academy of Sciences of the United States of America·Thai-Yen LingJohn Yu
Jun 3, 2014·Stem Cell Research & Therapy·Thomas S KlarićMartin D Lewis
Nov 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Shuibing ChenSheng Ding
May 20, 2014·Nature Chemical Biology·Toni PfaffenederThomas Carell
Jan 21, 2014·Cellular and Molecular Life Sciences : CMLS·Sanjay SinhaAlessandra Granata
Nov 24, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ichiro HirataniDavid M Gilbert
Apr 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Frederick E Tan, Michael B Elowitz
Dec 5, 2013·ELife·Poshen B ChenThomas G Fazzio
Mar 20, 2014·Cellular and Molecular Life Sciences : CMLS·Giuseppe LupoFederico Cremisi
Aug 26, 2009·Biotechnology Letters·Tiago G FernandesJoaquim M S Cabral
Mar 4, 2014·Differentiation; Research in Biological Diversity·James Nicholas HughesJoy Rathjen
Oct 8, 2014·Annual Review of Cell and Developmental Biology·Graziano Martello, Austin Smith
Nov 26, 2014·Tissue Engineering. Part C, Methods·Krista M FridleyTodd C McDevitt
Apr 7, 2010·Cell Stem Cell·Debbie L C van den BergRaymond A Poot
Aug 27, 2014·Trends in Neurosciences·Mandana ArbabNiels Geijsen
Dec 7, 2007·Stem Cell Reviews·Cui P ChenRandall D McKinnon
May 7, 2011·Human Cell·Makoto OsonoiShinichi Abe
Aug 28, 2003·Médecine sciences : M/S·Anne-Catherine FluckigerPierre Savatier
Jan 5, 2006·The Journal of Cell Biology·Simon R SmuklerDerek van der Kooy
Apr 8, 2009·The Journal of Cell Biology·Cristina GontanRobbert J Rottier
Oct 4, 2005·Expert Opinion on Biological Therapy·Hitoshi Fukuda, Jun Takahashi
Aug 15, 2014·Stem Cell Research·Yu-Rim KwonJong-Sun Kang
Feb 7, 2016·Biochemical and Biophysical Research Communications·Ke LiShaohua Xu
May 16, 2015·International Journal of Molecular Medicine·Bang-Jin KimBuom-Yong Ryu
Oct 21, 2015·Proceedings of the National Academy of Sciences of the United States of America·Haixia ChenLingyi Chen
Dec 3, 2014·Stem Cell Research·Jianyu WuY Alex Zhang
Jan 28, 2016·Nature·Maud de DieuleveultMatthieu Gérard
Jan 1, 2013·Journal of Genetics and Genomics = Yi Chuan Xue Bao·Zhenkun WangQi Zhou
Oct 12, 2012·Experimental Cell Research·Zhongwei Li, Ye-Guang Chen
Apr 18, 2012·Molecular and Cellular Neurosciences·James J RitchKimberly B Kegel
Jan 11, 2016·Acta Neurologica Scandinavica·A E Pen, U B Jensen
Apr 3, 2012·Differentiation; Research in Biological Diversity·Cynthia AddaeEduardo Martinez-Ceballos
Oct 18, 2011·Neuroscience Research·Berry JuliandiKinichi Nakashima
Sep 7, 2011·Biochemical and Biophysical Research Communications·Lining LiuDebashish Das
Jun 7, 2011·Pharmacology & Therapeutics·Chihiro Tohda, Tomoharu Kuboyama
Mar 29, 2011·American Journal of Otolaryngology·Bryony A Nayagam, Ricki L Minter
Feb 22, 2011·Journal of Molecular Biology·Mikaël AttiaUte Christine Rogner
Oct 26, 2010·Current Opinion in Neurobiology·Mirza Peljto, Hynek Wichterle
Jul 3, 2010·Science China. Life Sciences·Teng Fei, Ye-Guang Chen
Jun 29, 2010·Experimental Cell Research·Massimiliano CaiazzoUmberto di Porzio
Jan 19, 2010·Current Opinion in Neurobiology·Nicolas Gaspard, Pierre Vanderhaeghen
Oct 17, 2009·Biochemical and Biophysical Research Communications·Mark D SinghGerard J Graham
Nov 26, 2009·Molecular and Cellular Neurosciences·Elke Muth-KöhneMichael Hollmann
Nov 7, 2009·Cytokine & Growth Factor Reviews·Eve SeuntjensDanny Huylebroeck
Mar 5, 2016·Biochemical and Biophysical Research Communications·Penghua YangPeixin Yang
Sep 30, 2009·Biochemical and Biophysical Research Communications·Yincheng TengMinfang Tao
Sep 15, 2009·Biochimica Et Biophysica Acta·Chien-Tsun ChenYau-Huei Wei
Feb 24, 2015·Molecular Cell·Zhuojuan LuoAli Shilatifard
Jul 18, 2009·Differentiation; Research in Biological Diversity·Zhixing HuYongchang Chen
Dec 9, 2008·Neuroscience Letters·Joelle AlcockVirginie Sottile
Jul 16, 2008·Molecular and Cellular Neurosciences·J LarssonKarin Forsberg-Nilsson
Jul 16, 2008·Molecular and Cellular Neurosciences·Matthew T Lorincz, Virginia A Zawistowski
May 10, 2008·Neuroscience Letters·Biju ParekkadanMartin L Yarmush
Oct 9, 2007·Journal of the Neurological Sciences·Alexis J Joannides, Siddharthan Chandran
Oct 30, 2007·Journal of the Neurological Sciences·Tamara GlaserOliver Brüstle
Oct 16, 2007·Journal of the Neurological Sciences·R Laguna GoyaRoger A Barker
Jul 24, 2007·Journal of Biotechnology·A M FernandesJoaquim M S Cabral
Jul 17, 2007·Comptes rendus biologies·Daniel AberdamMatthieu Rouleau
Mar 24, 2007·Trends in Biotechnology·Hazel Thomson
Mar 6, 2007·Current Opinion in Genetics & Development·Sara GiadrossiAmanda G Fisher
Jan 25, 2007·Neurosurgery Clinics of North America·Cleo Choong, Mahendra S Rao
Jan 25, 2007·Neurosurgery Clinics of North America·Daniel A LimArturo Alvarez-Buylla
Oct 31, 2006·Biochemical and Biophysical Research Communications·Huarong HuangMing Zhang
Jul 11, 2015·Acta Biomaterialia·Shahzad AliFarlan S Veraitch
Jun 9, 2005·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Nobuaki ShirakiShoen Kume
Sep 28, 2005·Journal of Anatomy·Sarah Maxwell, Meng Li
Dec 17, 2004·Journal of Cellular and Molecular Medicine·Roxana Nat, Outi Hovatta
Dec 21, 2005·Journal of Cellular and Molecular Medicine·Hong WeiKenneth R Boheler
Apr 23, 2005·The European Journal of Neuroscience·Lena SmirnovaF Gregory Wulczyn
Jun 23, 2009·Stem Cells·Timothy M LavauteSu-Chun Zhang
May 21, 2009·Biotechnology Progress·Paul Mondragon-TeranFarlan S Veraitch
Jun 21, 2008·The Journal of Pathology·David M Suter, K-H Krause
Sep 25, 2008·Developmental Neurobiology·Hedong LiMartin Grumet
Sep 2, 2008·Journal of Cellular Biochemistry·Sujoy K Dhara, Steven L Stice
Feb 7, 2009·Biotechnology Progress·Andrés M Bratt-LealTodd C McDevitt
Jul 25, 2008·Reproduction in Domestic Animals = Zuchthygiene·C Galli, G Lazzari
Sep 16, 2008·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Nobuyoshi KosakaTakahiro Ochiya
Jun 14, 2006·Brain Pathology·Björn SchefflerOliver Brüstle
Jun 14, 2006·Brain Pathology·Su-Chun Zhang
Nov 18, 2006·Stem Cells·Jelena BanMaria Elisabetta Ruaro
Sep 15, 2007·Neuropathology and Applied Neurobiology·Y A ChristouP N Monk
Jan 25, 2008·The European Journal of Neuroscience·Hideki HayashiJun Takahashi
Jul 19, 2008·Stem Cells·Tamara GlaserOliver Brüstle
Jul 19, 2008·Stem Cells·Delphine BohlJean-Michel Heard
Nov 6, 2007·Journal of Cellular and Molecular Medicine·Pascale V GuillotDame Julia Polak
Nov 11, 2006·Stem Cells·Alexis J JoannidesSiddharthan Chandran
Jul 19, 2012·Journal of Cellular Biochemistry·Olga MomčilovićXianmin Zeng
Sep 22, 2010·Journal of Neuroscience Research·Shinji KusakawaAkito Tanoue
Jul 28, 2011·Biotechnology Progress·Ana Fernandes-PlatzgummerJoaquim M S Cabral
Jun 21, 2012·Journal of Neuroscience Research·Zhourui WuGuoping Fan
Jun 10, 2011·Biotechnology and Bioengineering·Elisa MiglioriniMaria Elisabetta Ruaro
Jul 1, 2010·Journal of Cellular Biochemistry·Noélle GermainLaura Grabel
Aug 18, 2010·Stem Cells·Jared SterneckertHans R Schöler
Nov 13, 2010·Journal of Cellular and Molecular Medicine·Alessio NogheroAnna Gualandris
Mar 10, 2010·Journal of Biomedical Materials Research. Part a·Richard L CarpenedoTodd C McDevitt
Aug 15, 2012·Biotechnology Journal·Vassiliki Nikoletopoulou, Nektarios Tavernarakis
Nov 17, 2011·The EMBO Journal·Boris GreberHans R Schöler
Feb 11, 2011·Stem Cells·Claire E PickfordCatherine L R Merry
Oct 10, 2012·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Sophia L B OliveiraHenning Ulrich
Sep 10, 2013·Wiley Interdisciplinary Reviews. Developmental Biology·Mohammad Zeeshan OzairAli H Brivanlou
Sep 26, 2009·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Nyam-Osor Chimge, Dashzeveg Bayarsaihan
Dec 17, 2009·Biotechnology and Bioengineering·Carlos A V RodriguesJoaquim M S Cabral
Mar 26, 2010·Journal of Cellular Biochemistry·Santiago Nahuel VillegasJoshua M Brickman
Feb 24, 2010·Journal of Neurochemistry·Constantine James KonstantoulasMeng Li
Feb 11, 2010·Genesis : the Journal of Genetics and Development·Konstantinos AnastassiadisA Francis Stewart
Jan 14, 2010·Biotechnology and Bioengineering·Tiago G FernandesJonathan S Dordick
Mar 26, 2016·Biochemical and Biophysical Research Communications·Claudia SolariAlejandra Guberman
Oct 18, 2015·Journal of Bioscience and Bioengineering·Hideki Mori, Masayuki Hara
Aug 26, 2009·Journal of Neuroscience Research·Osamu TaoHideyuki Okano
Mar 26, 2005·Brain Research. Molecular Brain Research·Kai-Christian SonntagOle Isacson
Nov 3, 2004·Molecular and Cellular Neurosciences·Suling ZhaoMeng Li
Nov 9, 2004·Current Opinion in Cell Biology·Anna V MolofskySean J Morrison
Aug 22, 2006·Current Opinion in Genetics & Development·Francesca M Spagnoli, Ali Hemmati-Brivanlou
Jun 27, 2006·Brain Research·Virginie SottilePaul J Scotting
Jan 26, 2006·Experimental Neurology·Thomas BréjotDelphine Bohl
Dec 6, 2005·Brain Research Bulletin·Isabelle A BouhonNicholas D Allen
Aug 6, 2005·Molecular and Cellular Neurosciences·Pavel ItsyksonBenjamin E Reubinoff
Mar 21, 2006·Pathologie-biologie·O Goureau, J-A Sahel
Jun 28, 2012·Neurological Research·Nadine KraemerAngela M Kaindl
Jan 8, 2008·Differentiation; Research in Biological Diversity·Hossein BaharvandMansoureh Shahsavani
Sep 29, 2015·Research in Veterinary Science·Hoo Mun-FunNorshariza Nordin
Dec 6, 2014·Cell Death and Differentiation·A MustoS Parisi
Jan 27, 2011·Biochemical Society Transactions·Raymond A A SmithCatherine L R Merry
Apr 22, 2014·Current Opinion in Neurobiology·Stewart Anderson, Pierre Vanderhaeghen
May 23, 2014·Biochemical Society Transactions·Rebecca J HolleyCatherine L R Merry
Feb 11, 2015·Progress in Retinal and Eye Research·Sujatha A JayakodyRachael A Pearson
Aug 23, 2011·Molecular and Cellular Neurosciences·N A Slawny, K Sue O'Shea
Sep 1, 2009·Journal of Neuroscience Methods·Mathilda Zetterström AxellMaurice Curtis
Sep 15, 2009·Current Opinion in Genetics & Development·Sven Falk, Lukas Sommer
Feb 13, 2010·Developmental Biology·Malkiel A CohenBenjamin E Reubinoff
Jan 14, 2012·Systems Biology in Reproductive Medicine·Hyung-yul LeeDeborah K Hansen
Nov 16, 2011·Toxicology Mechanisms and Methods·Dae Hyun BaekTae Moo Yoo
Apr 20, 2012·Upsala Journal of Medical Sciences·Tobias Bergström, Karin Forsberg-Nilsson
Sep 23, 2014·Molecular Neurobiology·Ghanshyam UpadhyayRakesh K Srivastava
Apr 23, 2015·Stem Cells and Development·Giuseppe PettinatoNing Zhang
Dec 24, 2014·Cell Reports·William B Hamilton, Joshua M Brickman
May 27, 2014·Cell·Grigory KrapivinskyDavid E Clapham
Apr 1, 2015·Trends in Genetics : TIG·Mina GoutiJames Briscoe
Jul 1, 2015·Stem Cells International·Rita C Assunção-SilvaAntónio J Salgado
Jun 12, 2013·Cell Reports·Sophie M MorganiJoshua M Brickman
May 1, 2012·Cell·Hendrik MarksHendrik G Stunnenberg
Sep 21, 2007·Mechanisms of Development·Anthony VuglerPeter Coffey
Apr 23, 2014·Communicative & Integrative Biology·Yingying LuJianbo Yue
Nov 21, 2012·Cell Cycle·Tian Yun ZhaoLeah A Vardy
Mar 13, 2012·Current Opinion in Neurobiology·Mototsugu Eiraku, Yoshiki Sasai
May 26, 2011·Neuron·David V HansenArnold Kriegstein
Mar 24, 2015·Frontiers in Cellular Neuroscience·Svenja PacherneggMichael Hollmann
Apr 11, 2014·BioMed Research International·Lei HaoLei Liu
Nov 12, 2013·Molecular Cell·Siem van der LaanDomenico Maiorano
Dec 3, 2014·Stem Cell Research·Bradford A Youngblood, Clinton C MacDonald
Jun 5, 2008·Cell Stem Cell·Jun FujitaThomas P Zwaka
Jul 14, 2010·Cell Stem Cell·Xiaoqing ZhangSu-Chun Zhang
Dec 27, 2011·Cell·Qiaoran XiJoan Massagué
Jan 28, 2006·Cell·Elisabet AnderssonJohan Ericson
Dec 29, 2004·Cell·Mito Kanatsu-ShinoharaTakashi Shinohara
Feb 11, 2009·Cell·Jeong Beom KimHans R Schöler
Jun 10, 2014·Seminars in Cell & Developmental Biology·Fumiko ItohKohei Miyazono
Feb 13, 2004·Developmental Cell·Stephen W Wilson, Corinne Houart
Aug 13, 2013·Molecular Cell·Shi-Yan NgLawrence W Stanton
Jun 21, 2005·Developmental Biology·Jiwang Zhang, Linheng Li
Oct 22, 2008·Developmental Biology·José-Manuel Baizabal, Luis Covarrubias
Nov 15, 2008·Biochimica Et Biophysica Acta·Ruwani Wijeyekoon, Roger A Barker
Apr 22, 2014·Trends in Neurosciences·Jelle van den AmeeleIra Espuny-Camacho
Aug 31, 2014·Neurobiology of Aging·Sjoukje D KuipersAndrea Trentani
Feb 17, 2009·Developmental Biology·Mijeong KimJames E Huettner
Dec 3, 2014·Developmental Biology·Adam F LaingJoshua M Brickman
Apr 19, 2016·Nature Genetics·Madapura M PradeepaWendy A Bickmore
Mar 16, 2016·Journal of Bioscience and Bioengineering·Hidenori TaniMasaki Torimura
Jul 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Osahiko TsujiHideyuki Okano
May 31, 2016·Stem Cells International·Piya PrajumwongsParinya Noisa
May 14, 2016·Stem Cells and Development·Soojin KimDongho Geum
Jun 4, 2016·Cell Stem Cell·Iva Kelava, Madeline A Lancaster
Apr 24, 2007·Progress in Neurobiology·Steven M Pollard, Luciano Conti
Jul 28, 2016·Cell Reports·Laura GrassoVictoria H Cowling
Oct 11, 2016·ELife·Robert S IllingworthJoshua M Brickman
Oct 16, 2016·Proceedings of the National Academy of Sciences of the United States of America·Adrian RangaMatthias P Lutolf
Nov 9, 2016·Frontiers in Cellular Neuroscience·Philipp CapetianChristine Klein
Oct 27, 2016·Nature Medicine·Giorgia QuadratoPaola Arlotta
Dec 3, 2016·Wiley Interdisciplinary Reviews. Developmental Biology·Joshua M Brickman, Palle Serup
Jan 1, 2010·Biotechnology & Genetic Engineering Reviews·Gary AdamsNan Wang
Oct 26, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Shin Yong MoonDong-Wook Kim
Jan 23, 2016·PloS One·Queenie Wing-Lei WongLeah A Vardy
May 31, 2015·Stem Cells Translational Medicine·Haigang GuQi Zhang
Jan 26, 2017·Journal of Molecular Biology·Maxime BodakConstance Ciaudo
Aug 8, 2015·PloS One·Andreas H EhrensbergerJesper Q Svejstrup
Mar 21, 2017·Genesis : the Journal of Genetics and Development·Jonathan H ShermanThomas M Maynard
Jan 22, 2015·Scientific Reports·Mathias ErnstGeorg Fuellen
Oct 16, 2013·Scientific Reports·Masaki ShigetaHitoshi Niwa
Apr 5, 2017·Translational Psychiatry·M J MoenRaymond A Poot
May 16, 2014·Scientific Reports·Kenji SuehiroYoshinori Takei
Mar 26, 2014·Scientific Reports·S Cosson, Matthias P Lutolf
Feb 24, 2017·Journal of Cellular Biochemistry·Na LiJinlian Hua
Mar 10, 2017·Developmental Neurobiology·Matteo Ascenzi, Guillaume Bony
Apr 14, 2017·Integrative Biology : Quantitative Biosciences From Nano to Macro·Ramila JoshiHossein Tavana
Jun 8, 2017·Stem Cell Reports·Jamie A HackettM Azim Surani
Jun 15, 2007·Expert Review of Neurotherapeutics·Jun Takahashi
Jan 31, 2017·Scientific Reports·Jana KonířováMartina Zíková
Jul 10, 2013·The Journal of Biological Chemistry·Yingying LuJianbo Yue
Oct 21, 2011·International Journal of Toxicology·Dae Hyun BaekHyung Soo Kim
Nov 9, 2010·Cell Transplantation·Hung-Chuan PanHong-Lin Su