"Conversion" of epistatic into additive genetic variance in finite populations and possible impact on long-term selection response

Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie
W G Hill

Abstract

The role of epistasis in understanding the genetic architecture and variation of quantitative traits and its role, if any, in artificial selection and livestock improvement more generally has a long and sometimes controversial history. Its presence has been clearly demonstrated in, for example, laboratory experiments, but the amount of variation it contributes is likely to be small in outbred populations. In a finite population, although additive x additive epistatic variance is lost by genetic drift, it also contributes by conversion to additive variance through drift sampling and therefore has a potential indirect role in medium and long-term selection response, with superficial similarity to and hard to distinguish from mutation. Whilst predictions of response require knowledge of genetic parameters, an infinitesimal model provides some analytic results. Otherwise there is little quantitative information relevant to animal populations on which to judge this potential role of epistasis and reach firm conclusions.

References

Nov 26, 2004·Evolution; International Journal of Organic Evolution·N H Barton, Michael Turelli
Dec 20, 2005·Theoretical Population Biology·William G HillMichael Turelli
Mar 15, 2006·Nature Genetics·Orjan CarlborgLeif Andersson
May 6, 2008·PLoS Genetics·William G HillPeter M Visscher
Jul 15, 2009·Genetics·Andrés Pérez-FigueroaCarlos López-Fanjul
Jun 12, 2013·Journal of Dairy Science·Joaquim CasellasAndrés Legarra
Oct 29, 2013·Trends in Genetics : TIG·Ronald M NelsonÖrjan Carlborg
Dec 5, 2013·Evolution; International Journal of Organic Evolution·Thomas F Hansen
Apr 3, 2014·Evolution; International Journal of Organic Evolution·Victoria AvilaCarlos López-Fanjul
Jul 6, 2014·Genetics·Asko Mäki-Tanila, William G Hill
Jan 13, 2015·Genetics Research·Joaquim CasellasJuan F Medrano
May 20, 2015·Nature Genetics·Tinca J C PoldermanDanielle Posthuma
Apr 5, 2016·Proceedings of the National Academy of Sciences of the United States of America·Tiago Paixão, Nicholas H Barton
Nov 20, 2016·The American Naturalist·Arnaud Le Rouzic, José M Álvarez-Castro

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Citations

Sep 14, 2018·Proceedings. Biological Sciences·Evatt ChirgwinKeyne Monro
Dec 21, 2019·G3 : Genes - Genomes - Genetics·Pascal DuenkJulius H J van der Werf
Feb 13, 2020·Journal of Animal Science·Antonio ReverterAndrés Legarra
Jul 8, 2018·Heredity·Joshua A Banta, Christina L Richards
Dec 24, 2018·Genetics, Selection, Evolution : GSE·Zulma G VitezicaAndres Legarra
Apr 17, 2021·Nature Ecology & Evolution·Erik I SvenssonAnna Runemark
Apr 18, 2021·Genetics·David González-DiéguezZulma G Vitezica
Apr 20, 2021·Evolution Letters·Evatt ChirgwinKeyne Monro

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