PMID: 37503Jun 1, 1979Paper

Conversion of glutathione to glutathione disulfide by cell membrane-bound oxidase activity

Proceedings of the National Academy of Sciences of the United States of America
S S TateA Meister

Abstract

An apparently specific glutathione oxidase activity is present in renal cortex, epididymal caput, jejunal villus tip cells, choroid plexus, and retina (but not in liver). The activity is membrane-bound and is localized on the luminal surface of the brush border membranes of the kidney and jejunum. The distribution and localization of the oxidase are similar to those of gamma-glutamyl transpeptidase, suggesting that there is a significant relationship among the translocation of intracellular glutathione, the extracellular oxidation of glutathione to glutathione disulfide, and the reactions of the gamma-glutamyl cycle. Thus, both glutathione present in the blood plasma and intracellular glutathione translocated to the cell surface are accessible to oxidation and transpeptidation. Acceptor substrates of the transpeptidase (e.g., L amino acids) promote transpeptidation and decrease oxidation of glutathione. Conversion of glutathione to glutathione disulfide is followed by utilization of the latter compound by gamma-glutamyl transpeptidase and dipeptidase. Although intracellular oxidation of glutathione to glutathione disulfide is readily reversed by the action of glutathione reductase, glutathione disulfide formed extracellularly c...Continue Reading

References

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Citations

Sep 25, 1981·Molecular and Cellular Biochemistry·S S Tate, A Meister
Jan 1, 1980·The International Journal of Biochemistry·T M McIntyre, N P Curthoys
Nov 1, 1986·Mutation Research·D RossM T Smith
Jun 25, 1984·Biochimica Et Biophysica Acta·L H LashS Orrenius
Apr 13, 2013·Chemical Reviews·Min Hee LeeJong Seung Kim
Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·O W Griffith, A Meister
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·J MårtenssonA Meister
May 9, 2006·Antioxidants & Redox Signaling·Donald L Coppock, Colin Thorpe
Feb 19, 2009·The Journal of Pharmacology and Experimental Therapeutics·Pei-Suen TsouHo-Leung Fung
Jul 16, 1982·Biochemical and Biophysical Research Communications·C H SchmelzerH R Horton
Oct 15, 1981·Archives of Biochemistry and Biophysics·M B SliwkowskiH R Horton
Sep 22, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Alfonso PompellaMaria Franzini
Nov 28, 2007·Biochimica Et Biophysica Acta·H Reynaldo López-Mirabal, Jakob R Winther
Aug 3, 1981·FEBS Letters·K OrmstadS Orrenius
May 1, 1980·European Journal of Biochemistry·R GrafströmS Orrenius
Aug 18, 2020·Antioxidants & Redox Signaling·Colin G Miller, Edward E Schmidt
Aug 18, 2016·Journal of the American Chemical Society·Zhen ZhengGaolin Liang

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