Conversion of IGT to type 2 diabetes mellitus is associated with incident cases of hypertension: a post-hoc analysis of the STOP-NIDDM trial

Journal of Hypertension
Markolf HanefeldJean Louis Chiasson

Abstract

Type 2 diabetes mellitus and hypertension are closely associated and contribute together to microvascular and macrovascular end-organ damage. Prevalence of hypertension is increased even in the prediabetic state. However, there is little information available about the relationship between incidence of hypertension and a deterioration of glucose tolerance from impaired glucose tolerance (IGT) to diabetes. To clarify these issues we analysed data from the Stop non insulin dependent diabetes mellitus (STOP-NIDDM) trial - a prospective interventional study for the prevention of type 2 diabetes in people with prediabetes using the alpha-glucosidase inhibitor acarbose. Hypertension was already present at study entry in 702 (51.3%) of 1368 patients who were eligible for intention-to-treat analysis. A total of 96 out of the 666 normotensive individuals at baseline developed hypertension during the 3.3-year follow-up. The strongest risk factors for time to development of hypertension were abdominal obesity at baseline [hazard ratio 1.91, 95% confidence interval (CI) 1.19-3.05, P < 0.01] and worsening of glucose tolerance (hazard ratio 1.54, 95% CI 1.02-2.32, P < 0.05), whereas acarbose treatment reduced the risk of hypertension (hazard...Continue Reading

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Citations

Oct 25, 2012·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Christoph Rosak, Gabriele Mertes
Apr 20, 2014·Cardiovascular Diabetology·Eberhard StandlJaakko Tuomilehto
Mar 10, 2016·Reviews in Endocrine & Metabolic Disorders·Markolf HanefeldAndreas L Birkenfeld
Aug 11, 2015·Expert Opinion on Pharmacotherapy·Shashank R JoshiRahul Rathod
May 12, 2016·Reviews in Endocrine & Metabolic Disorders·Christian A KochAndreas L Birkenfeld
Feb 15, 2019·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jeffrey I MechanickW Timothy Garvey
Mar 5, 2021·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Yingkui SiZhaohui Lyu

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