PMID: 3113487Sep 4, 1987Paper

Conversion of linoleic acid and arachidonic acid by skin epidermal lipoxygenases

Biochimica Et Biophysica Acta
D H Nugteren, G A Kivits


Two different lipoxygenases have been identified in human and rat epidermis. One lipoxygenase has a (n-9)-specificity, converts arachidonic acid into 12-hydroxyeicosatetraenoic acid (12-HETE), and has been described by several investigators. Linoleic acid is not a substrate for this enzyme. The other lipoxygenase, with (n-6)-specificity, converts arachidonic acid into 15-HETE and linoleic acid into 13-hydroxyoctadecadienoic acid (13-HOD). Especially the latter lipoxygenase is thought to be involved in the regulation of the differentiation of the skin cells into a proper water-barrier layer. Linoleate is supposed to be the physiological substrate; this fatty acid is especially present in characteristic sphingolipids with unique structures.


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Oct 23, 1985·Biochimica Et Biophysica Acta·M ClaeysD H Nugteren
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