PMID: 3113487Sep 4, 1987Paper

Conversion of linoleic acid and arachidonic acid by skin epidermal lipoxygenases

Biochimica Et Biophysica Acta
D H Nugteren, G A Kivits

Abstract

Two different lipoxygenases have been identified in human and rat epidermis. One lipoxygenase has a (n-9)-specificity, converts arachidonic acid into 12-hydroxyeicosatetraenoic acid (12-HETE), and has been described by several investigators. Linoleic acid is not a substrate for this enzyme. The other lipoxygenase, with (n-6)-specificity, converts arachidonic acid into 15-HETE and linoleic acid into 13-hydroxyoctadecadienoic acid (13-HOD). Especially the latter lipoxygenase is thought to be involved in the regulation of the differentiation of the skin cells into a proper water-barrier layer. Linoleate is supposed to be the physiological substrate; this fatty acid is especially present in characteristic sphingolipids with unique structures.

References

Feb 1, 1979·Lipids·L D Tobias, J G Hamilton
Aug 1, 1979·The Journal of Investigative Dermatology·S HammarströmJ J Voorhees
Oct 23, 1985·Biochimica Et Biophysica Acta·M ClaeysD H Nugteren
May 17, 1985·Biochimica Et Biophysica Acta·D H NugterenU M Houtsmuller
Nov 27, 1985·Biochemical and Biophysical Research Communications·B A BurrallE J Goetzl
May 17, 1985·Biochimica Et Biophysica Acta·P A BowserC Prottey
May 16, 1983·Biochimica Et Biophysica Acta·T RuzickaM P Printz
Mar 21, 1983·FEBS Letters·H KühnS M Rapoport
Sep 1, 1983·Prostaglandins·R D CampM W Greaves
Jan 1, 1981·Progress in Lipid Research·U M Houtsmuller, A van der Beek

❮ Previous
Next ❯

Citations

Sep 1, 1990·Prostaglandins·G HonstraW Uedelhoven
Dec 1, 1992·Prostaglandins·G BioqueE Gelpi
Dec 5, 2000·Prostaglandins & Other Lipid Mediators·L Iversen, K Kragballe
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·A R BrashM S Chang
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·W E BoeglinA R Brash
Jan 1, 1988·Nutrition Research Reviews·T A Sanders
Dec 1, 1991·The British Journal of Dermatology·S Wright
Nov 15, 1994·Annals of the New York Academy of Sciences·A R BrashW Song
Aug 21, 2013·Biochimica Et Biophysica Acta·Peter Krieg, Gerhard Fürstenberger
Jul 5, 2007·The FEBS Journal·Alan R BrashClaus Schneider
Jan 1, 1995·Prostaglandins, Leukotrienes, and Essential Fatty Acids·F Grimminger, P Mayser
Oct 15, 1991·Biochemical and Biophysical Research Communications·A N BaerF A Green
Jun 15, 1989·Biochemical and Biophysical Research Communications·O ReinaudD Mansuy
Jun 26, 1999·The Journal of Investigative Dermatology·E N JohnsonC D Funk
Jul 10, 2001·The Journal of Investigative Dermatology·S B ShappellA R Brash
Oct 30, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Matthias SchmuthVerena Moosbrugger-Martinz
Jan 1, 1995·Rapid Communications in Mass Spectrometry : RCM·G BioqueE Gelpí
Oct 1, 1995·Molecular Carcinogenesis·P KriegG Fürstenberger
Sep 20, 1996·The Journal of Biological Chemistry·C D FunkA R Brash
Dec 1, 1988·Hypertension·R J GryglewskiJ R Vane
Oct 28, 2015·Journal of the American Heart Association·Sandrine Ellero-SimatosUNKNOWN Pharmacometabolomics Research Network
Apr 6, 1995·Biochimica Et Biophysica Acta·L LomnitskiS Grossman
Sep 18, 1990·Biochimica Et Biophysica Acta·C HadjiagapiouH Sprecher
Jan 1, 1988·Progress in Lipid Research·A A SpectorS A Moore
May 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·M Vasänge-TuominenW Rolfsen
Aug 1, 1991·The Journal of Investigative Dermatology·H H Henneicke-von ZepelinE Christophers

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.