PMID: 6972436Feb 1, 1981Paper

Conversion of monocytes to cells capable of anchorage-independent growth in vitro

The Journal of Experimental Medicine
H S LinM Kurtz

Abstract

We investigated the time-course involved in the conversion of mouse blood monocytes in vitro in cells capable of anchorage-independent growth. Two criteria were used to define when monocytes were fully converted to cells similar to mononuclear phagocytes present in inflammatory exudate, such as thioglycollate medium (TM)-elicited peritoneal exudate. They were the production of high levels of plasminogen activators and an ability to undergo anchorage-independent growth. Resident peritoneal macrophages were used as controls and for comparison. Our studies indicated that monocytes, but not resident peritoneal macrophages, could be converted to cells similar to TM-elicited mononuclear phagocytes after 2 d in culture.

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Citations

Apr 16, 1982·Molecular and Cellular Biochemistry·V J Hruby

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