PMID: 7028652Oct 1, 1981Paper

Conversion of potentially lethal damage to lethal damage in Escherichia coli inhibited by caffeine

International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine
B Koukalová, J Reich

Abstract

In E. coli cells with potentially lethal damage to their DNA are starved of amino acids they rapidly lose viability (Koukalová and Kuhrová 1980). This phenomenon is called secondary lethality (SL). In the course of secondary lethality there is a decrease in the molecular weight of DNA to a value on average three times lower (DNA fragmentation, and part of the DNA is reduced to acid-soluble fractions (DNA degradation). Caffeine inhibits SL, and both these processes of DNA decay, The lowest effective concentration 5 mg/ml, with maximum effect at a concentration of 10 mg/ml. SL is also inhibited by the absence of an energy source. The possible mechanism of SL is discussed on the basis of these results.

References

Jan 25, 1978·Journal of Molecular Biology·E N JacksonM L Adams
Aug 1, 1978·Photochemistry and Photobiology·K C Smith
Feb 1, 1975·Journal of Bacteriology·H Nakayama, P Hanawalt
Jun 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·G F Strniste, S S Wallace
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Dec 20, 1974·Biochimica Et Biophysica Acta·Y M Kupersztoch-Portroy, D R Helinski
May 1, 1980·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·B Koukalová, V Kuhrová

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Citations

Nov 11, 2011·International Journal of Molecular Sciences·Garry LavertyBrendan F Gilmore

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