PMID: 8945073Nov 1, 1996Paper

Conversion of recent onset atrial fibrillation with single loading oral dose of propafenone: is in-hospital admission absolutely necessary?

Pacing and Clinical Electrophysiology : PACE
G L BottoG Ferrari

Abstract

A population of 283 patients with recent onset (< 72 hours) AF, without heart failure, who received a single 450- or 600-mg oral dose of propafenone, or digoxin 1 mg, or placebo for conversion to sinus rhythm (SR), was studied to determine whether a routine admission to the hospital for drug administration is justified. Previous bradyarrhythmias or sick sinus syndrome (SSS), and concomitant use of antiarrhythmic drugs were exclusion criteria. None of the 283 patients studied experienced VT or VF and none of them needed implantation of a temporary pacemaker. Periods of atrial tachyarrhythmias with regularization of atrial waves and 1:1 AV conduction were observed in only two cases, both receiving placebo. No predictor of proarrhythmia was found among the clinical variables considered (age, etiology, arrhythmia duration, atrial dimension, and blood potassium). No serious hemodynamic adverse effects were noted in either group. The rates of conversion to SR after 4 hours were: 80 (57%) of 141 patients who received propafenone and 35 (25%) of 142 patients who received digoxin or placebo (P < 0.001). Acute oral treatment with propafenone is simple and effective for the conversion of recent onset AF to SR in patients without clinical ...Continue Reading

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Citations

Jan 26, 2005·Zeitschrift für Kardiologie·J R Ehrlich, S H Hohnloser
Nov 11, 1998·The American Journal of Cardiology·A P Rae
Dec 3, 2004·The New England Journal of Medicine·Paolo AlboniGermano Gaggioli
Jul 4, 2003·Postgraduate Medical Journal·A Wakai, J O O'Neill
May 5, 2012·Heart, Lung & Circulation·Kugathasan Nadarasa, Michael J A Williams
Jun 22, 2006·The American Journal of Emergency Medicine·Stavros E MountantonakisCraig A McPherson
Mar 5, 2004·Cardiology Clinics·Robert A VerNooy, J Paul Mounsey
Nov 26, 2003·The American Journal of Cardiology·Alessandro CapucciMassimo F Piepoli
Aug 18, 2004·Journal of the American College of Cardiology·John A ChiladakisAntonis S Manolis
Sep 25, 2001·Progress in Cardiovascular Diseases·R S SlavikS Borzak
May 19, 1998·Pacing and Clinical Electrophysiology : PACE·C CosteasJ A Reiffel
Apr 22, 2006·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·David SchwartzmanDavid E Euler

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