Conversion ratios of n-3 fatty acids between plasma and erythrocytes: a systematic review and meta-regression

The British Journal of Nutrition
Xue Feng HuHing Man Chan

Abstract

As biomarkers of dietary intake or disease risk factor, n-3 fatty acid (FA) can be measured in plasma phospholipids (PL), total lipids (TL) or erythrocytes. However, the numeric relationships between n-3 FA in these lipid pools are not clear. Our goal was to derive conversion ratios for plasma and erythrocyte n-3 FA. Potential studies were identified through systematic literature search in PubMed, Embase and the Cochrane Library of Systematic reviews (1950 to October 2014). In all, fifty-six studies reporting n-3 in healthy individuals were included, of which thirty-four articles reported plasma PL and erythrocytes, and twenty-two reported plasma TL and erythrocytes. Meta-regressions were performed to quantify the ratio between plasma and erythrocyte n-3 FA weight percentages, controlling for covariates including age, sex and study design. The conversion ratios from plasma PL to erythrocytes for EPA, DHA, DPA and total n-3 PUFA are 0·75, 1·16, 2·32 and 1·22; the corresponding conversion ratios from plasma TL to erythrocytes are 1·00, 2·10, 3·85 and 2·08, respectively. The conversion ratios were validated using reported values from the literature and measured data from fifty individuals. The relative error of the predicted resul...Continue Reading

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Citations

Nov 30, 2019·Lipids·Adam H MetherelRobert C Block
Mar 21, 2018·Current Atherosclerosis Reports·Kristina H Jackson, William S Harris
Jan 23, 2021·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Federico M DarayM Elizabeth Sublette

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