Conversion towards an atherogenic lipid profile in rheumatoid arthritis patients during long-term infliximab therapy

Scandinavian Journal of Rheumatology
S Rantapää DahlqvistO Johnson

Abstract

To analyse the effects of infliximab infusions on serum levels of lipids in patients with rheumatoid arthritis (RA) treated for 2 years. Fifty-two patients (41 females and 11 males) with RA undergoing infliximab treatment (3 mg/kg) were consecutively recruited into the study. The mean (+/-SD) age of the patients was 54.6+/-12.5 years and mean disease duration was 14.1+/-8.6 years. Blood was sampled before infusion at baseline, and at 3, 6, 12, 18 and 24 months. Forty-one of the patients were also treated with methotrexate, 13 with other disease-modifying anti-rheumatic drugs (DMARDs) and 28 with prednisolone (<10 mg daily). For comparison, lipid levels were followed for 2 years in 70 consecutively included patients with early RA during treatment with conventional DMARDs. There was an initial increase in plasma levels of cholesterol, high density lipoprotein (HDL)-cholesterol, low density lipoprotein (LDL)-cholesterol, and LDL/HDL and total/HDL cholesterol ratios. However, after 3 months HDL-cholesterol decreased significantly, followed after 6 months by cholesterol and LDL-cholesterol. The LDL/HDL and total/HDL-cholesterol ratios remained significantly raised. HDL-cholesterol increased and the ratios improved in patients with e...Continue Reading

References

Jun 1, 1991·Annals of the Rheumatic Diseases·S Rantapää-DahlqvistG Dahlén
Jul 1, 1995·Scandinavian Journal of Clinical and Laboratory Investigation·S Wållberg-JonssonS Rantapää-Dahlqvist
Aug 26, 1998·The American Journal of Medicine·M H Criqui, B A Golomb
Jun 4, 1999·Seminars in Cell & Developmental Biology·J K Sethi, G S Hotamisligil
Apr 16, 2002·Arthritis and Rheumatism·S Van DoornumI P Wicks
May 29, 2004·Current Opinion in Lipidology·Lucia RohrerArnold von Eckardstein
Sep 4, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Lena BrånénStefan Jovinge
Oct 30, 2004·Scandinavian Journal of Rheumatology·D O Haskard
Apr 22, 2005·The New England Journal of Medicine·Göran K Hansson

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Citations

Apr 7, 2010·Metabolic Syndrome and Related Disorders·Smriti K RaychaudhuriSiba P Raychaudhuri
Sep 3, 2011·Arthritis Research & Therapy·Michael H SchiffRonald F van Vollenhoven
May 18, 2010·Joint, Bone, Spine : Revue Du Rhumatisme·Adeline Ruyssen-WitrandThao Pham
Jun 19, 2009·Journal of the American Academy of Dermatology·Bruce StroberMelodie Young
May 1, 2009·Reumatología clinica·Ricardo Blanco Alonso, Mario Agudo Bilbao
Sep 25, 2007·Joint, Bone, Spine : Revue Du Rhumatisme·Martin SoubrierJean Michel Ristori
May 8, 2007·Journal of the American Academy of Dermatology·Kassie A Haitz, Robert E Kalb
Sep 17, 2009·Cell Biochemistry and Function·Xiuping ChenYitao Wang
Jul 14, 2007·The British Journal of Dermatology·W SterryUNKNOWN International Psoriasis Council
Oct 6, 2007·The British Journal of Dermatology·G StincoP Patrone
Sep 8, 2011·Arthritis and Rheumatism·Lotta LjungUNKNOWN Anti-Rheumatic Therapy in Sweden (ARTIS) Study Group
Jun 18, 2010·Cardiovascular Therapeutics·Louise E Full, Claudia Monaco
Apr 27, 2010·Dermatologic Therapy·Gino A VenaNicoletta Cassano
Sep 3, 2011·Annales de cardiologie et d'angéiologie·C I Daïen, P Fesler
Dec 21, 2016·Journal of Comparative Effectiveness Research·Jingyang LiWendong Chen
Mar 23, 2017·British Journal of Pharmacology·Fatima IqbalDemidmaa Tuvdendorj
Apr 18, 2008·Current Atherosclerosis Reports·Saurabh S Dhawan, Arshed A Quyyumi
Mar 18, 2009·Inflammatory Bowel Diseases·Erika Parmentier-DecrucqLaurent Peyrin-Biroulet
Jan 11, 2018·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Michael NurmohamedPaola Accossato
Apr 3, 2012·The Journal of Rheumatology·Androniki BiliMary Chester Wasko
Jul 9, 2008·Current Opinion in Lipidology·Sahena HaqueIan N Bruce
Jun 12, 2009·Clinical Rheumatology·Raquel Cuchacovich, Luis R Espinoza
Apr 13, 2010·Clinical Rheumatology·Eduardo Nicolas PollonoMaria E Suarez-Almazor
Sep 24, 2010·Zeitschrift für Rheumatologie·I H TarnerC Hamm
Mar 10, 2011·Nature Reviews. Rheumatology·Ronald F van Vollenhoven
Feb 15, 2008·The Journal of Dermatological Treatment·Alice B GottliebFrank Dann
Nov 1, 2011·The Journal of Dermatology·Hidetoshi Takahashi, Hajime Iizuka
Dec 4, 2012·Dermatology and Therapy·Bruce E StroberMelodie Young
May 4, 2007·Scandinavian Journal of Rheumatology·A RosenvingeB K Pedersen
Mar 8, 2013·Current Opinion in Rheumatology·Medha Barbhaiya, Daniel H Solomon
Mar 7, 2021·Expert Review of Clinical Immunology·George A KarpouzasSarah R Ormseth

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