PMID: 8967400Apr 1, 1996Paper

Converting enzyme inhibitors cause pressure-independent resetting of baroreflex control of sympathetic outflow

The American Journal of Physiology
C M HeeschJ A Turbek

Abstract

The current study was performed to determine whether baroreflex resetting after acute administration of converting enzyme inhibitors (CEIs) was dependent on the concomitant decrease in mean arterial pressure (MAP). Reflex changes in lumbar sympathetic nerve activity (LSNA) due to increases and decreases in MAP [i.v. phenylephrine (PE) and nitroprusside infusions] were determined in normotensive and renal hypertensive (1-kidney, 1-clip) anesthetized WKY rats 1) before (control), 2) 15 min after intravenous captopril (2 mg/kg) or enalaprilat (300 micrograms), and 3) 15 min after MAP was returned to pre-CEI levels with intravenous PE. CEIs decreased MAP and caused a leftward shift of the MAP-LSNA curve toward a lower operating pressure range in all hypertensive and in one group of normotensive rats. The baroreflex curve remained shifted to the left even after MAP was restored to pre-CEI levels by infusion of PE. Thus CEIs cause a pressure-independent resetting of baroreflex control of sympathetic outflow within 15 min. This effect of CEIs is most likely due to elimination of a central nervous system effect of circulating angiotensin II and could contribute to the antihypertensive actions of this class of compounds.

Citations

May 28, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Virginia L BrooksCheryl M Heesch
Sep 25, 2015·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Friedhelm SaykChristoph Dodt
Mar 29, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M VitelaS W Mifflin
Apr 18, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Max G Sanderford, Vernon S Bishop
Jan 13, 2006·Clinical and Experimental Pharmacology & Physiology·Michael TraubMark M Knuepfer

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