Convolutional Neural Network for Histopathological Analysis of Osteosarcoma

Journal of Computational Biology : a Journal of Computational Molecular Cell Biology
Rashika MishraAnita Sengupta

Abstract

Pathologists often deal with high complexity and sometimes disagreement over osteosarcoma tumor classification due to cellular heterogeneity in the dataset. Segmentation and classification of histology tissue in H&E stained tumor image datasets is a challenging task because of intra-class variations, inter-class similarity, crowded context, and noisy data. In recent years, deep learning approaches have led to encouraging results in breast cancer and prostate cancer analysis. In this article, we propose convolutional neural network (CNN) as a tool to improve efficiency and accuracy of osteosarcoma tumor classification into tumor classes (viable tumor, necrosis) versus nontumor. The proposed CNN architecture contains eight learned layers: three sets of stacked two convolutional layers interspersed with max pooling layers for feature extraction and two fully connected layers with data augmentation strategies to boost performance. The use of a neural network results in higher accuracy of average 92% for the classification. We compare the proposed architecture with three existing and proven CNN architectures for image classification: AlexNet, LeNet, and VGGNet. We also provide a pipeline to calculate percentage necrosis in a given w...Continue Reading

References

Mar 10, 2010·Cancer Treatment and Research·Giulia Ottaviani, Norman Jaffe
Sep 28, 2010·Human Pathology·Marion J PollheimerCord Langner
Aug 21, 2013·Journal of the American Medical Informatics Association : JAMIA·Sonal KothariMay D Wang
Feb 11, 2016·IEEE Transactions on Medical Imaging·Korsuk SirinukunwattanaNasir M Rajpoot
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Oct 27, 2017·Journal of Healthcare Engineering·Zeju LiYing Mao

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Citations

Jan 7, 2020·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Danni CuiLei Liu
Apr 12, 2020·Cancer Communications·Yahui JiangYan Sun
Nov 5, 2019·Frontiers in Bioengineering and Biotechnology·Shachi MittalRohit Bhargava
Feb 1, 2020·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William D TravisYasushi Yatabe
May 21, 2021·Skeletal Radiology·Matthew D LiConnie Y Chang
Jul 1, 2021·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Zhineng ChenXieping Gao
Aug 21, 2021·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·T Y Alvin LiuNeil R Miller

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Methods Mentioned

BETA
biopsies
feature extraction
PCA

Software Mentioned

Aperio
AlexNet
VGGNet
Lenet
dl4j
JAVA

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