Convolutional Neural Networks for Neuroimaging in Parkinson's Disease: Is Preprocessing Needed?

International Journal of Neural Systems
Francisco J Martinez-MurciaAndres Ortiz

Abstract

Spatial and intensity normalizations are nowadays a prerequisite for neuroimaging analysis. Influenced by voxel-wise and other univariate comparisons, where these corrections are key, they are commonly applied to any type of analysis and imaging modalities. Nuclear imaging modalities such as PET-FDG or FP-CIT SPECT, a common modality used in Parkinson's disease diagnosis, are especially dependent on intensity normalization. However, these steps are computationally expensive and furthermore, they may introduce deformations in the images, altering the information contained in them. Convolutional neural networks (CNNs), for their part, introduce position invariance to pattern recognition, and have been proven to classify objects regardless of their orientation, size, angle, etc. Therefore, a question arises: how well can CNNs account for spatial and intensity differences when analyzing nuclear brain imaging? Are spatial and intensity normalizations still needed? To answer this question, we have trained four different CNN models based on well-established architectures, using or not different spatial and intensity normalization preprocessings. The results show that a sufficiently complex model such as our three-dimensional version o...Continue Reading

References

Sep 8, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J MazziottaB Mazoyer
Feb 17, 2005·International Journal of Neural Systems·Kyungsun KimJungyun Seo
Jul 20, 2010·NeuroImage·Martin ReuterBruce Fischl
Oct 9, 2012·Medical Physics·I A IllanS J Ortega Lozano
Jan 1, 2013·International Journal of Neural Systems·Larry D Olson, M Scott Perry
Dec 3, 2014·Neural Networks : the Official Journal of the International Neural Network Society·Jürgen Schmidhuber
Mar 10, 2015·Neuroinformatics·D Salas-GonzalezElmar W Lang
May 29, 2015·Nature·Yann LeCunGeoffrey Hinton
Jul 28, 2015·Nature Biotechnology·Babak AlipanahiBrendan J Frey
Oct 1, 2015·Journal of Medical Systems·Thomas J HirschauerJohn A Buford
Aug 6, 2016·Molecular Informatics·Erik GawehnGisbert Schneider
Oct 7, 2017·International Journal of Neural Systems·Linqiang PanFerrante Neri

❮ Previous
Next ❯

Citations

Mar 25, 2018·Neuroinformatics·Manhua LiuUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jul 31, 2020·International Journal of Neural Systems·A ApicellaG Tamburrini
Jul 18, 2019·Frontiers in Neuroinformatics·Andrés OrtizDiego Salas-Gonzalez
May 30, 2019·Journal of Medical Systems·Betul AyU Rajendra Acharya
Aug 14, 2020·International Journal of Neural Systems·Diego Castillo-BarnesJuan M Górriz
Nov 20, 2020·Frontiers in Neuroinformatics·Javier RamírezMartin Dyrba
May 25, 2021·Frontiers in Aging Neuroscience·Jie MeiJohannes Frasnelli
Jul 3, 2021·Healthcare·Mahmood Saleh AlzubaidiMowafa Househ
Sep 4, 2020·International Journal of Neural Systems·Andrés Gómez-RodellarPedro Gómez-Vilda
Dec 16, 2021·Computer Methods and Programs in Biomedicine·David López-GarcíaMaría Ruz
Oct 20, 2020·Computers in Biology and Medicine·Pavan Rajkumar MageshRijo Jackson Tom

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Margarida Silveira, Pedro M Q Aguiar
Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society
H Cecotti
© 2022 Meta ULC. All rights reserved