Convulsant and anticonvulsant effects of bupropion in mice

European Journal of Pharmacology
Piotr TutkaMarian Wielosz

Abstract

This study demonstrated that bupropion hydrochloride, an effective antidepressant and a commonly used smoking cessation aid, dose-dependently caused clonic convulsions in mice, with the CD50 (convulsive dose50, i.e., the dose producing convulsions in 50% of mice) at 119.7 mg kg(-1). An evaluation for anticonvulsant effects showed that bupropion in the doses of 15-30 mg kg(-1) protected against convulsions induced by maximal electroshock with the ED50 (effective dose50, i.e., the dose protected 50% of mice against convulsions) being 19.4 mg kg(-1). Bupropion had no effect on pentylenetetrazole- and kainic acid-induced convulsions. It is possible that the anticonvulsant activity of bupropion may be exploited for use in the treatment of epilepsy but it requires further investigations.

Citations

Aug 19, 2008·Annals of General Psychiatry·Peter H SilverstoneSiobhan Fogarty
Oct 17, 2008·Annals of General Psychiatry·Peter H SilverstoneSiobhan Fogarty
Dec 25, 2008·Annals of General Psychiatry·Peter H SilverstoneSiobhan Fogarty
Jun 27, 2009·Neuropsychiatric Disease and Treatment·David C HenshallPeter H Silverstone
Nov 3, 2010·European Journal of Pharmacology·Bartłomiej BarczyńskiPiotr Tutka
Nov 14, 2012·British Journal of Pharmacology·L CardamoneN C Jones
May 4, 2005·Epilepsy Research·Piotr TutkaMarian Wielosz
Dec 11, 2007·Epilepsy & Behavior : E&B·Alcy R TorresJoseph Gonzalez-Heydrich
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Jun 19, 2013·Progress in Neuro-psychopharmacology & Biological Psychiatry·Kao-Chang LinSu-Jane Wang
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Apr 4, 2021·International Journal of Molecular Sciences·Kinga K Borowicz-Reutt

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