PMID: 2505297Jan 1, 1989Paper

Convulsant properties of GABA antagonists and anticonvulsant properties of ethanol in selectively bred long- and short-sleep mice

Psychopharmacology
T J PhillipsB C Dudek

Abstract

The convulsant potency of bicuculline, a GABA antagonist, was shown to be greater in Short-Sleep (SS) mice than in Long-Sleep (LS) mice. LS mice, selectively bred for lengthy ethanol-induced narcosis, had longer latencies to myoclonus and clonus following administration of bicuculline and picrotoxin than did ethanol-resistant SS mice. SS mice were also more susceptible to pentylenetetrazol-induced myoclonus, but not clonus. F1 hybrids showed bicuculline seizure sensitivity intermediate to the two parent lines. Ethanol weakly inhibited bicuculline-induced myoclonus in both LS and SS mice. Clonus was clearly antagonized by ethanol in both lines, but to a similar degree. These data provide evidence for a GABAergic role in genotype-dependent sensitivity to ethanol.

References

Jun 1, 1976·Pharmacology, Biochemistry, and Behavior·V G ErwinR A Deitrich
Dec 17, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·J CottM Lindqvist
Jan 1, 1989·Psychopharmacology·B C Dudek, T J Phillips
Jan 1, 1983·Neuroscience and Biobehavioral Reviews·W A Hunt
Apr 1, 1984·Journal of Neurochemistry·D A GreenbergI Diamond
Apr 22, 1983·European Journal of Pharmacology·A MartzR A Harris

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Citations

Jan 1, 1989·Psychopharmacology·B C Dudek, T J Phillips
Sep 15, 1989·Experientia·T J PhillipsJ C Crabbe
Oct 1, 1994·Alcoholism, Clinical and Experimental Research·D L DaviesR L Alkana
Mar 1, 1996·Journal of Pineal Research·T H ChampneyK Appel

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