PMID: 6406779May 30, 1983Paper

Convulsions induced by submaximal dose of pentylenetetrazol in mice are antagonized by the benzodiazepine antagonist Ro 15-1788

Life Sciences
G GreckschJ Rossier

Abstract

The effects of benzodiazepine antagonist Ro 15-1788, alone or with diazepam, were studied in mice on convulsions induced by pentylenetetrazol (PTZ). We found that Ro 15-1788 (1 mg/kg) was able to antagonize the anticonvulsive effects of diazepam (1 mg/kg), but also had, with submaximal doses of PTZ (65 mg/kg), its own anticonvulsive action. At very low doses (0.1 mg/kg), it even potentiated the anticonvulsive effects of diazepam (0.05 mg/kg). This dual action provides evidence for partial agonist properties of the antagonist Ro 15-1788.

References

Apr 9, 1981·Nature·W HunkelerW Haefely
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Citations

Jan 1, 1986·Psychopharmacology·S E File, S Pellow
Jan 1, 1984·European Journal of Clinical Pharmacology·Y LupoloverA Assimacopoulos
Jul 13, 1984·European Journal of Pharmacology·C MarescauxJ M Warter
Aug 17, 1984·European Journal of Pharmacology·L Prado de CarvalhoJ Rossier
Nov 13, 1984·European Journal of Pharmacology·M CharveronM Briley
Jun 19, 1985·European Journal of Pharmacology·L Pieri, P Biry
Mar 18, 1986·European Journal of Pharmacology·A Y ChwehE A Swinyard
Oct 7, 1986·European Journal of Pharmacology·L Prado de CarvalhoJ Rossier
Apr 14, 1987·European Journal of Pharmacology·J W Phillis, R E Stair
Oct 26, 1988·European Journal of Pharmacology·M C PotierJ Rossier
May 28, 1984·Life Sciences·C L MelchiorB Tabakoff
Apr 1, 1984·Neuropharmacology·S E FileJ C Tucker
Aug 1, 1985·Pharmacology, Biochemistry, and Behavior·S K Rastogi, M K Ticku
Sep 1, 1987·Pharmacology, Biochemistry, and Behavior·C BelzungG Chapouthier
Mar 1, 1993·Pharmacology, Biochemistry, and Behavior·J RathouskáJ Vorlícek
Dec 1, 1995·Pharmacology, Biochemistry, and Behavior·R J RodgersL H Stephenson
Jan 19, 1991·Lancet·I SavicS Stone-Elander
Jan 1, 1984·Neuroscience and Biobehavioral Reviews·S Pellow, S E File
Jan 1, 1985·Neuroscience and Biobehavioral Reviews·S Pellow
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Jan 1, 1984·Progress in Neuro-psychopharmacology & Biological Psychiatry·J W Phillis
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Sep 19, 2003·Pharmacology, Biochemistry, and Behavior·Anshu ManochaKrishna Kishore Sharma
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Jan 1, 1995·Acta Anaesthesiologica Scandinavica. Supplementum·J G Whitwam, R Amrein
Feb 26, 2000·Epilepsia·A Schulze-Bonhage, C E Elger
Oct 1, 1991·Pharmacology, Biochemistry, and Behavior·P S Grigson, C F Flaherty

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