PMID: 3772379Dec 1, 1986Paper

Convulsive activity of alpha-guanidinoglutaric acid and the possible involvement of 5-hydroxytryptamine in the alpha-guanidinoglutaric acid-induced seizure mechanism

Journal of Neurochemistry
H ShiragaA Mori

Abstract

alpha-Guanidinoglutaric acid (alpha-GGA) was first found in cobalt-induced epileptogenic focus tissue in the cerebral cortex of cats. We examined the effect of alpha-GGA on the electroencephalogram and on the brain 5-hydroxytryptamine (5-HT) level after intraventricular administration into rats. Sporadic low-voltage spikes appeared 4 min after the administration of alpha-GGA. Spikes increased in voltage 6 min after the administration. Multiple spikes appeared 10 min after the administration, and they reached maximal frequency 30 min after the administration. The epileptic discharges disappeared 100 min after the administration. The 5-HT level increased in the right and left cortices 3 min after the administration. The 5-HT level decreased in the mid-brain 5 min after the administration and subsequently in all regions of the brain 10 min after the administration. No change in the 5-HT level was found 30 min and 100 min after the administration. These results show that alpha-GGA induces epileptic seizures in rats after intraventricular administration. The results also suggest that alpha-GGA-induced seizures are associated with abnormal serotonergic function and that they are initiated by a decrease in the 5-HT level.

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Citations

Oct 1, 1991·Neurochemical Research·Y WatanabeA Mori
May 1, 1958·Electroencephalography and Clinical Neurophysiology·B L RALSTON
Oct 1, 1978·Electroencephalography and Clinical Neurophysiology·I Sherwin
Dec 1, 1983·Electroencephalography and Clinical Neurophysiology·H H LangeP H Crandall
Mar 5, 2003·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Daniela BalzMaria Rosa Chitolina Schetinger
Jun 5, 2003·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Alexandra I ZugnoAngela T S Wyse
Jul 6, 2010·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Daniela Delwing-de LimaDébora Delwing-Dal Magro
Jul 13, 2004·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Alexandra I ZugnoAngela T S Wyse
Jan 29, 2005·British Journal of Pharmacology·Tania O SteanNeil Upton

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