Cooking enhances beneficial effects of pea seed coat consumption on glucose tolerance, incretin, and pancreatic hormones in high-fat-diet-fed rats

Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme
Zohre HashemiCatherine B Chan

Abstract

Pulses, including dried peas, are nutrient- and fibre-rich foods that improve glucose control in diabetic subjects compared with other fibre sources. We hypothesized feeding cooked pea seed coats to insulin-resistant rats would improve glucose tolerance by modifying gut responses to glucose and reducing stress on pancreatic islets. Glucose intolerance induced in male Sprague-Dawley rats with high-fat diet (HFD; 10% cellulose as fibre) was followed by 3 weeks of HFD with fibre (10%) provided by cellulose, raw-pea seed coat (RP), or cooked-pea seed coat (CP). A fourth group consumed low-fat diet with 10% cellulose. Oral and intraperitoneal glucose tolerance tests (oGTT, ipGTT) were done. CP rats had 30% and 50% lower glucose and insulin responses in oGTT, respectively, compared with the HFD group (P < 0.05) but ipGTT was not different. Plasma islet and incretin hormone concentrations were measured. α- and β-cell areas in the pancreas and density of K- and L-cells in jejunum and ileum were quantified. Jejunal expression of hexose transporters was measured. CP feeding increased fasting glucagon-like peptide 1 and glucose-stimulated gastric inhibitory polypeptide responses (P < 0.05), but K- and L-cells densities were comparable to ...Continue Reading

References

Dec 1, 1982·The American Journal of Clinical Nutrition·D J JenkinsT Francis
Oct 13, 2001·Plant Physiology·N C CarpitaM C McCann
Jan 30, 2002·The American Journal of Clinical Nutrition·Katri S JuntunenHannu M Mykkänen
Mar 1, 1997·The Plant Cell·N. CarpitaL. R. Griffing
Dec 25, 2002·The British Journal of Nutrition·F Guillon, M M-J Champ
Dec 28, 2002·Diabetes Care·Ioannis N LegakisCostas Phenekos
Oct 3, 2003·The American Journal of Clinical Nutrition·Simon SchenkEdward F Coyle
Mar 26, 2004·European Journal of Clinical Nutrition·Z X LuK O'Dea
Mar 29, 2006·Diabetes Care·Martin O WeickertAndreas F H Pfeiffer
Feb 15, 2008·Diabetes/metabolism Research and Reviews·Monique C SalehCatherine B Chan
Feb 22, 2008·The Journal of Nutrition·Martin O Weickert, Andreas F H Pfeiffer
Sep 11, 2008·American Journal of Physiology. Endocrinology and Metabolism·Lindsey N SutherlandDavid C Wright
Dec 17, 2008·Pharmacological Reviews·Wook Kim, Josephine M Egan
Feb 5, 2010·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Joshua Tarini, Thomas M S Wolever
May 25, 2010·Journal of Food Science·Christopher P F MarinangeliPeter J H Jones
Sep 17, 2010·The Journal of Clinical Endocrinology and Metabolism·Ram WeissSonia Caprio
Feb 2, 2011·PloS One·Zhuo LiuJosephine M Egan
Jul 21, 2011·Journal of Nutrition and Metabolism·Marianne S H LundeArne T Høstmark
Aug 17, 2011·Diabetes, Obesity & Metabolism·D D'Alessio
Oct 27, 2011·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Christopher P F MarinangeliPeter J H Jones
Jan 19, 2012·Nutrients·James M Lattimer, Mark D Haub
Aug 25, 2012·The British Journal of Nutrition·Kevin A WhitlockCatherine B Chan
Oct 9, 2013·European Journal of Nutrition·Scott V HardingPeter J H Jones
Apr 22, 2010·Journal of Diabetes Investigation·Yutaka SeinoDaisuke Yabe
Jun 17, 2014·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Catherine B ChanKaiyuan Yang
Aug 27, 2014·Nutrition Research·Amanda J EslingerRaylene A Reimer

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