COOL AMI EU pilot trial: a multicentre, prospective, randomised controlled trial to assess cooling as an adjunctive therapy to percutaneous intervention in patients with acute myocardial infarction

EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology
Marko NocMichael Holzer

Abstract

We aimed to investigate the rapid induction of therapeutic hypothermia using the ZOLL Proteus Intravascular Temperature Management System in patients with anterior ST-elevation myocardial infarction (STEMI) without cardiac arrest. A total of 50 patients were randomised; 22 patients (88%; 95% confidence interval [CI]: 69-97%) in the hypothermia group and 23 patients (92%; 95% CI: 74-99) in the control group completed cardiac magnetic resonance imaging at four to six days and 30-day follow-up. Intravascular temperature at coronary guidewire crossing after 20.5 minutes of endovascular cooling decreased to 33.6°C (range 31.9-35.5°C). There was a 17-minute (95% CI: 4.6-29.8 min) cooling-related delay to reperfusion. In "per protocol" analysis, median infarct size/left ventricular mass was 16.7% in the hypothermia group versus 23.8% in the control group (absolute reduction 7.1%, relative reduction 30%; p=0.31) and median left ventricular ejection fraction (LVEF) was 42% in the hypothermia group and 40% in the control group (absolute reduction 2.4%, relative reduction 6%; p=0.36). Except for self-terminating paroxysmal atrial fibrillation (32% versus 8%; p=0.074), there was no excess of adverse events in the hypothermia group. We rapi...Continue Reading

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Citations

Jan 23, 2018·Therapeutic Hypothermia and Temperature Management·Kees PoldermanThomas Keeble
Oct 19, 2017·Biomarkers in Medicine·Christoph SinningPeter Clemmensen
Aug 23, 2017·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Luuk C OtterspoorNico H J Pijls
Aug 25, 2018·Therapeutic Hypothermia and Temperature Management·Thomas R KeebleNoel Watson
Sep 29, 2018·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Yong-Sheng WangLian-Sheng Wang
Nov 10, 2018·Therapeutic Hypothermia and Temperature Management·Marko NocPhilip E Empey
Jan 8, 2019·Therapeutic Hypothermia and Temperature Management·Michael C KurzMarko Noc
Jun 23, 2019·Cardiovascular Research·Bernard I LevyPaolo G Camici
Aug 7, 2017·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Darren Mylotte, Robert A Byrne
Sep 16, 2017·Neurocritical Care·Jonathan Elmer, Kees H Polderman
Apr 19, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Brunilda AlushiSalvatore Cassese
Jan 10, 2018·Expert Review of Cardiovascular Therapy·Sebastian NudingRoland Prondzinsky
Jun 20, 2020·Therapeutic Hypothermia and Temperature Management·Luis Augusto Palma DallanSergio Timerman
Apr 13, 2018·Deutsches Ärzteblatt International·Jan SmidRüdiger C Braun-Dullaeus
Mar 5, 2021·Frontiers in Cardiovascular Medicine·Kelly P YamadaKiyotake Ishikawa
Jul 17, 2021·Circulation. Cardiovascular Interventions·Mohamed El FarissiLuuk C Otterspoor
May 26, 2021·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Marko NocThomas R Keeble
Aug 30, 2021·JACC. Cardiovascular Interventions·Marko NocUrsa Mikuz

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